Interrogation of related clinical pan-azole-resistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter (Q38726518)

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scientific article published on 29 August 2011

Language	Label	Description	Also known as
English	Interrogation of related clinical pan-azole-resistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter	scientific article published on 29 August 2011

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scholarly article

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11 February 2020

Interrogation of related clinical pan-azole-resistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter (English)

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11 February 2020

Aspergillus fumigatus

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ABC multidrug transporter

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5 February 2019

14-alpha sterol demethylase

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6 February 2019

ABC multidrug transporter

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6 February 2019

single-nucleotide polymorphism

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based on heuristic

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David W. Denning

7

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3

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Dominique Sanglard

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author name string

Ahmed M Albarrag

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Michael J Anderson

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11 February 2020

Geoff D Robson

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11 February 2020

Peter A Warn

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29 August 2011

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Antimicrobial Agents and Chemotherapy

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55

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5113-5121

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11 February 2020

describes a project that uses

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11 June 2022

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Global burden of chronic pulmonary aspergillosis as a sequel to pulmonary tuberculosis

1 reference

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Acquired antifungal drug resistance in Aspergillus fumigatus: epidemiology and detection.

1 reference

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Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism

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6 September 2017

Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus

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6 September 2017

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Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

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6 September 2017

Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility.

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In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance

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1 reference

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Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase

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Identification of two different 14-alpha sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other Aspergillus species

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Resistance to itraconazole in Aspergillus nidulans and Aspergillus fumigatus is conferred by extra copies of the A. nidulans P-450 14alpha-demethylase gene, pdmA.

1 reference

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Microsatellite markers for typing Aspergillus fumigatus isolates

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6 September 2017

Itraconazole resistance in Aspergillus fumigatus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195044

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Molecular typing by random amplification of polymorphic DNA and M13 southern hybridization of related paired isolates of Aspergillus fumigatus

1 reference

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1 reference

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14 September 2017

A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus

1 reference

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Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure

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Characterisation of Aft1 a Fot1/Pogo type transposon of Aspergillus fumigatus

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A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.

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10.1128/AAC.00517-11

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11 February 2020

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11 February 2020

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