Nuclear Factor Erythroid-2 Like 1 (NFE2L1): Structure, function and regulation (Q38762571)

6 September 2017

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Nuclear Factor Erythroid-2 Like 1 (NFE2L1): Structure, function and regulation (English)

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6 September 2017

part of the series

Gene Wiki Review Series

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author name string

Hyun Min Kim

series ordinal

1

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6 September 2017

Jeong Woo Han

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2

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6 September 2017

Jefferson Y Chan

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3

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6 September 2017

language of work or name

English

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publication date

3 March 2016

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6 September 2017

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6 September 2017

volume

584

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6 September 2017

issue

1

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6 September 2017

page(s)

17-25

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Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3

6 September 2017

cites work

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12 December 2020

The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts

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12 December 2020

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

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12 December 2020

Expression of the bZIP transcription factor TCF11 and its potential dimerization partners during development

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12 December 2020

Two domains of the human bZIP transcription factor TCF11 are necessary for transactivation

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12 December 2020

TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter

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12 December 2020

Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice.

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12 December 2020

Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene

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12 December 2020

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

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12 December 2020

Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of Mammalian proteasomes

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12 December 2020

Comprehensive identification of human bZIP interactions with coiled-coil arrays

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12 December 2020

Nrf1 is critical for redox balance and survival of liver cells during development

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12 December 2020

SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response

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12 December 2020

Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress

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12 December 2020

Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element

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12 December 2020

Protein degradation and protection against misfolded or damaged proteins

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12 December 2020

The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation

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12 December 2020

Molecular machines for protein degradation

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12 December 2020

Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia

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12 December 2020

Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1

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12 December 2020

Structure of the leucine zipper

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12 December 2020

Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function

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12 December 2020

Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum

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12 December 2020

Activating transcription factor 4.

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12 December 2020

Nuclear factor-E2-related factor-1 mediates ascorbic acid induction of osterix expression via interaction with antioxidant-responsive element in bone cells

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12 December 2020

The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription

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12 December 2020

The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation.

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12 December 2020

Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11.

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12 December 2020

Endoplasmic reticulum association and N-linked glycosylation of the human Nrf3 transcription factor

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12 December 2020

Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators?

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12 December 2020

Regulation of glutathione synthesis

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12 December 2020

Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes

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12 December 2020

The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors

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12 December 2020

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

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12 December 2020

Segmentally restricted, cephalic expression of a leucine zipper gene during Drosophila embryogenesis

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12 December 2020

Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice

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12 December 2020

Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells

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12 December 2020

Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane

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12 December 2020

Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes

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12 December 2020

Feedback regulation of proteasome gene expression and its implications in cancer therapy

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12 December 2020

Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback Loop

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12 December 2020

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

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12 December 2020

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

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12 December 2020

Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration

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12 December 2020

Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.

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12 December 2020

NFE2L3 (NRF3): the Cinderella of the Cap'n'Collar transcription factors

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12 December 2020

Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms

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12 December 2020

The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis

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12 December 2020

The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia

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12 December 2020

Nrf1 CNC-bZIP protein promotes cell survival and nucleotide excision repair through maintaining glutathione homeostasis.

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12 December 2020

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12 December 2020

Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability

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12 December 2020

Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes

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12 December 2020

Nrf1 is time-dependently expressed and distributed in the distinct cell types after trauma to skeletal muscles in rats

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12 December 2020

Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1

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12 December 2020

Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice

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12 December 2020

The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression

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12 December 2020

p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition

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12 December 2020

The role of Nrf1 and Nrf2 in the regulation of copper-responsive transcription

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12 December 2020

Identification of novel transcription factors in osteoclast differentiation using genome-wide analysis of open chromatin determined by DNase-seq

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12 December 2020

Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97

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12 December 2020

Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice

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12 December 2020

Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes

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12 December 2020

Transcriptional regulation of dentin matrix protein 1 (DMP1) in odontoblasts and osteoblasts

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12 December 2020

The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression

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12 December 2020

CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion

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12 December 2020

Induction of Herpud1 expression by ER stress is regulated by Nrf1

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12 December 2020

Discovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system.

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12 December 2020

mTORC1 signaling activates NRF1 to increase cellular proteasome levels

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12 December 2020

The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression

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12 December 2020

Structural organization and mapping of the human TCF11 gene

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12 December 2020

Cloning and mapping of murine Nfe2l1.

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12 December 2020

Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization

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12 December 2020

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

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12 December 2020

Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression

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12 December 2020

Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast

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12 December 2020

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein

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12 December 2020

Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1

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12 December 2020

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

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12 December 2020

Functional antioxidant responsive elements.

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12 December 2020

Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif

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12 December 2020

Multiple regions of p45 NF-E2 are required for beta-globin gene expression in erythroid cells

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12 December 2020

hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2

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12 December 2020

Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription

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12 December 2020

Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice

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12 December 2020

A novel splice variant of the transcription factor Nrf1 interacts with the TNFalpha promoter and stimulates transcription.

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12 December 2020

Nrf1 in a complex with fosB, c-jun, junD and ATF2 forms the AP1 component at the TNF alpha promoter in stimulated mast cells

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12 December 2020

Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes

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12 December 2020

10.1016/J.GENE.2016.03.002

Identifiers

DOI

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6 September 2017

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