SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. (Q38768033)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27234298%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

title

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27234298%20AND%20SRC:MED&resulttype=core&format=json

SUFU negative regulator of hedgehog signaling

3 April 2020

main subject

medulloblastoma

0 references

1 reference

F-box and leucine rich repeat protein 17

1 reference

negative regulation of smoothened signaling pathway

1 reference

SUFU negative regulator of hedgehog signaling

1 reference

1 reference

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27234298%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Sébastien Serres

3

1 reference

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3 April 2020

Roman Fischer

6

1 reference

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3 April 2020

John C Christianson

10

1 reference

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3 April 2020

Vincenzo D'Angiolella

16

1 reference

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3 April 2020

author name string

Madalina Raducu

1

1 reference

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3 April 2020

Ella Fung

2

1 reference

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3 April 2020

Paola Infante

4

1 reference

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3 April 2020

Alessandro Barberis

5

1 reference

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3 April 2020

Claire Bristow

7

1 reference

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3 April 2020

Marie-Laëtitia Thézénas

8

1 reference

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3 April 2020

Csaba Finta

9

1 reference

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3 April 2020

Nicola R Sibson

13

1 reference

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3 April 2020

Lucia Di Marcotullio

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27234298%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Rune Toftgård

15

1 reference

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3 April 2020

Francesca M Buffa

11

1 reference

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3 April 2020

language of work or name

English

0 references

publication date

27 May 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27234298%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27234298%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

volume

35

1 reference

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3 April 2020

issue

13

1 reference

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3 April 2020

page(s)

1400-1416

1 reference

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Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.

3 April 2020

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6 September 2017

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6 September 2017

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Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium

6 September 2017

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A high-resolution anatomical atlas of the transcriptome in the mouse embryo

6 September 2017

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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

6 September 2017

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6 September 2017

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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

6 September 2017

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

6 September 2017

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Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma

6 September 2017

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6 September 2017

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S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

6 September 2017

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SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

6 September 2017

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Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

6 September 2017

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Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing

6 September 2017

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Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

6 September 2017

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Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused

6 September 2017

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Communicating with Hedgehogs

6 September 2017

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Systematic analysis and nomenclature of mammalian F-box proteins

6 September 2017

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Activation of the hedgehog pathway in advanced prostate cancer

6 September 2017

1 reference

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Suppressor of fused regulates Gli activity through a dual binding mechanism

6 September 2017

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Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

6 September 2017

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Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

6 September 2017

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Characterization of the physical interaction of Gli proteins with SUFU proteins

6 September 2017

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Mutations in SUFU predispose to medulloblastoma

6 September 2017

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An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

6 September 2017

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

6 September 2017

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Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

6 September 2017

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Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

6 September 2017

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A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

6 September 2017

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A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids

6 September 2017

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A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila

6 September 2017

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14 September 2017

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Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.

14 September 2017

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Hedgehog signalling in prostate regeneration, neoplasia and metastasis

14 September 2017

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14 September 2017

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Germline mutations in SUFU cause Gorlin syndrome-associated childhood medulloblastoma and redefine the risk associated with PTCH1 mutations

14 September 2017

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Two cases of nevoid basal cell carcinoma syndrome associated with meningioma caused by a PTCH1 or SUFU germline mutation

23 June 2018

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A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

23 June 2018

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Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin-proteasome pathway

23 June 2018

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Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma

23 June 2018

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Structural and functional effects of metastases in rat brain determined by multimodal MRI.

31 August 2018

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Identification of a SUFU germline mutation in a family with Gorlin syndrome.

31 August 2018

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Loss of suppressor-of-fused function promotes tumorigenesis.

31 August 2018

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Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.

31 August 2018

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SnapShot: F Box Proteins II

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27234298

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.15252/EMBJ.201593374

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27234298%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27234298%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

PubMed publication ID

27234298

1 reference