Novel activities by ebolavirus and marburgvirus interferon antagonists revealed using a standardized in vitro reporter system (Q38785678)

6 September 2017

Novel activities by ebolavirus and marburgvirus interferon antagonists revealed using a standardized in vitro reporter system (English)

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6 September 2017

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4

Jonathan S Towner

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6 September 2017

Jonathan C Guito

1

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6 September 2017

César G Albariño

series ordinal

2

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6 September 2017

Ayan K Chakrabarti

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3

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6 September 2017

language of work or name

English

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publication date

5 December 2016

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6 September 2017

19

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published in

Virology

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6 September 2017

501

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6 September 2017

147-165

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Signalling pathways of the TNF superfamily: a double-edged sword

6 September 2017

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Recombinant Marburg viruses containing mutations in the IID region of VP35 prevent inhibition of Host immune responses

7 January 2021

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Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection

7 January 2021

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Marburgvirus resurgence in Kitaka Mine bat population after extermination attempts, Uganda

7 January 2021

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Oral shedding of Marburg virus in experimentally infected Egyptian fruit bats (Rousettus aegyptiacus).

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Defining emerging roles for NF-κB in antivirus responses: revisiting the interferon-β enhanceosome paradigm

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Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism

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Innate immune evasion by filoviruses

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The Ebola virus VP35 protein functions as a type I IFN antagonist.

7 January 2021

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The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.

7 January 2021

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Rift Valley fever virus vaccine lacking the NSs and NSm genes is safe, nonteratogenic, and confers protection from viremia, pyrexia, and abortion following challenge in adult and pregnant sheep

7 January 2021

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Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation

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Discussions and decisions of the 2012–2014 International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group, January 2012–June 2013.

7 January 2021

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Neglected filoviruses

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Evasion of the interferon-mediated antiviral response by filoviruses

7 January 2021

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Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling

7 January 2021

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Molecular evolution of viruses of the family Filoviridae based on 97 whole-genome sequences

7 January 2021

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Correlating the ability of VP24 protein from Ebola and Marburg viruses to bind human karyopherin to their immune suppression mechanism and pathogenicity using computational methods

7 January 2021

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Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery

7 January 2021

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A Single Dose Respiratory Recombinant Adenovirus-Based Vaccine Provides Long-Term Protection for Non-Human Primates from Lethal Ebola Infection

7 January 2021

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High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus

7 January 2021

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Predictive and comparative analysis of Ebolavirus proteins

7 January 2021

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Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses

7 January 2021

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Marburg Virus VP24 Protein Relieves Suppression of the NF-κB Pathway Through Interaction With Kelch-like ECH-Associated Protein 1.

7 January 2021

1 reference

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Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins

7 January 2021

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The VP40 protein of Marburg virus exhibits impaired budding and increased sensitivity to human tetherin following mouse adaptation

7 January 2021

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Lloviu virus VP24 and VP35 proteins function as innate immune antagonists in human and bat cells.

7 January 2021

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Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action

7 January 2021

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Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function

7 January 2021

1 reference

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Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

7 January 2021

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The Ebolavirus VP24 protein blocks phosphorylation of p38 mitogen-activated protein kinase

7 January 2021

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The interferon response circuit: induction and suppression by pathogenic viruses

7 January 2021

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Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells

7 January 2021

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Reverse genetic generation of recombinant Zaire Ebola viruses containing disrupted IRF-3 inhibitory domains results in attenuated virus growth in vitro and higher levels of IRF-3 activation without inhibiting viral transcription or replication

7 January 2021

1 reference

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Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein

7 January 2021

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Inhibition of IRF-3 activation by VP35 is critical for the high level of virulence of ebola virus

7 January 2021

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Hostile takeovers: viral appropriation of the NF-kB pathway

7 January 2021

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Interferons and viruses: an evolutionary arms race of molecular interactions

7 January 2021

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Regulation of STAT pathways and IRF1 during human dendritic cell maturation by TNF-alpha and PGE2.

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Different Temporal Effects of Ebola Virus VP35 and VP24 Proteins on Global Gene Expression in Human Dendritic Cells

7 January 2021

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Experimental Inoculation of Egyptian Rousette Bats (Rousettus aegyptiacus) with Viruses of the Ebolavirus and Marburgvirus Genera

7 January 2021

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Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence

7 January 2021

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

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7 January 2021

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Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression

7 January 2021

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The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response

7 January 2021

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7 January 2021

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Evaluation of perceived threat differences posed by filovirus variants

7 January 2021

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Structure of the Ebola VP35 interferon inhibitory domain

7 January 2021

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Structural and Functional Characterization of Reston Ebola Virus VP35 Interferon Inhibitory Domain

7 January 2021

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Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35

7 January 2021

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Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes

7 January 2021

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Induction and regulation of IFNs during viral infections

7 January 2021

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Ebolavirus VP24 binding to karyopherins is required for inhibition of interferon signaling

7 January 2021

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VP24 is a molecular determinant of Ebola virus virulence in guinea pigs.

7 January 2021

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Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus

7 January 2021

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RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.

7 January 2021

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Anti-TNF-alpha therapies: the next generation

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Conserved differences in protein sequence determine the human pathogenicity of Ebolaviruses.

7 January 2021

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IRF-3 activation by Sendai virus infection is required for cellular apoptosis and avoidance of persistence

7 January 2021

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Filoviral immune evasion mechanisms

7 January 2021

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Structural basis for Marburg virus VP35-mediated immune evasion mechanisms

7 January 2021

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Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1.

7 January 2021

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Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation

7 January 2021

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poly(I:C) and LPS induce distinct IRF3 and NF-κB signaling during type-I IFN and TNF responses in human macrophages

7 January 2021

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Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7

7 January 2021

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Ebola virus VP35 antagonizes PKR activity through its C-terminal interferon inhibitory domain

7 January 2021

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Forty years of marburg virus

7 January 2021

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Evolutionary maintenance of filovirus-like genes in bat genomes

7 January 2021

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Marburg virus infection detected in a common African bat

7 January 2021

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Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda

7 January 2021

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Isolation of genetically diverse Marburg viruses from Egyptian fruit bats

7 January 2021

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Marburg virus VP40 antagonizes interferon signaling in a species-specific manner.

7 January 2021

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Marburg Virus Evades Interferon Responses by a Mechanism Distinct from Ebola Virus

7 January 2021

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NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication

7 January 2021

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Characterization of host immune responses in Ebola virus infections

7 January 2021

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Type I interferon: a new player in TNF signaling

7 January 2021

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Negative regulation of interferon-β gene expression during acute and persistent virus infections

7 January 2021

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Molecular basis for ebolavirus VP35 suppression of human dendritic cell maturation.

7 January 2021

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Virus Multiplicity of Infection Affects Type I Interferon Subtype Induction Profiles and Interferon-Stimulated Genes

7 January 2021

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The ebolavirus VP24 interferon antagonist: know your enemy

7 January 2021

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The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold

7 January 2021

1 reference

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Strategies of highly pathogenic RNA viruses to block dsRNA detection by RIG-I-like receptors: hide, mask, hit.

7 January 2021

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10.1016/J.VIROL.2016.11.015

7 January 2021

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6 September 2017

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