Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function (Q38786652)

5 October 2017

Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function (English)

1 reference

5 October 2017

P German

1

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1 June 2020

S Bai

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M Sun

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L Zhou

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S Kalra

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X Zhang

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R Minelli

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K L Scott

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E Jonasch

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Z Ding

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language of work or name

English

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publication date

14 March 2016

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5 October 2017

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1 June 2020

volume

35

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1 June 2020

issue

38

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1 June 2020

page(s)

4973-4980

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describes a project that uses

1 June 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5086402/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth

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VHL, the story of a tumour suppressor gene

23 June 2018

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Protein kinase CK2 inhibition is associated with the destabilization of HIF-1α in human cancer cells

23 June 2018

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Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein

23 June 2018

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Proteostasis modulators prolong missense VHL protein activity and halt tumor progression

23 June 2018

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

23 June 2018

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Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis

23 June 2018

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VHL gene mutations and their effects on hypoxia inducible factor HIFα: identification of potential driver and passenger mutations

23 June 2018

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VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo

23 June 2018

1 reference

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Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors

23 June 2018

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A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners

23 June 2018

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A CK2-dependent mechanism for degradation of the PML tumor suppressor

23 June 2018

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Role for casein kinase 2 in the regulation of HIF-1 activity

23 June 2018

1 reference

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Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain

23 June 2018

1 reference

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

23 June 2018

1 reference

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Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding

23 June 2018

1 reference

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von Hippel-Lindau disease

23 June 2018

1 reference

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Irreversible inhibitors of serine, cysteine, and threonine proteases

23 June 2018

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Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products

23 June 2018

1 reference

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Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC.

23 June 2018

1 reference

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

23 June 2018

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pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

23 June 2018

1 reference

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A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

23 June 2018

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Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

23 June 2018

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Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C

23 June 2018

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Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations

23 June 2018

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23 June 2018

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Phosphorylation of the von Hippel-Lindau protein (VHL) by protein kinase CK2 reduces its protein stability and affects p53 and HIF-1alpha mediated transcription

31 August 2018

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Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer.

31 August 2018

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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

31 August 2018

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Protein kinase CK2 in mammary gland tumorigenesis

31 August 2018

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31 August 2018

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Asymmetric expression of protein kinase CK2 subunits in human kidney tumors

31 March 2020

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Crossref

https://api.crossref.org/works/10.1038%2FONC.2016.40

31 March 2020

Identifiers

DOI

10.1038/ONC.2016.40

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26973240%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26973240%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

26973240

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26973240%20AND%20SRC:MED&resulttype=core&format=json