VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo (Q37154944)

18 August 2017

VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo (English)

1 reference

18 August 2017

7

W K Rathmell

1 reference

18 August 2017

C M Lee

1

1 reference

18 August 2017

M M Hickey

2

1 reference

18 August 2017

C A Sanford

3

1 reference

18 August 2017

C G McGuire

4

1 reference

18 August 2017

C L Cowey

5

1 reference

18 August 2017

M C Simon

6

1 reference

18 August 2017

language of work or name

English

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publication date

2 March 2009

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18 August 2017

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18 August 2017

28

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18 August 2017

14

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18 August 2017

1694-1705

1 reference

https://scigraph.springernature.com/pub.10.1038/onc.2009.12

18 August 2017

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cites work

VHL type 2B mutations retain VBC complex form and function

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Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors

6 September 2017

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VHL inactivation in renal cell carcinoma: implications for diagnosis, prognosis and treatment

6 September 2017

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von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis

6 September 2017

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Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells

6 September 2017

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Transplacental lung carcinogenesis: molecular mechanisms and pathogenesis

6 September 2017

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Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

6 September 2017

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Targeting HIF-1 for cancer therapy

6 September 2017

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Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

6 September 2017

1 reference

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Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

6 September 2017

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Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

6 September 2017

1 reference

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Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

6 September 2017

1 reference

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Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

6 September 2017

1 reference

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Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

6 September 2017

1 reference

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

6 September 2017

1 reference

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A conserved family of prolyl-4-hydroxylases that modify HIF

6 September 2017

1 reference

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

6 September 2017

1 reference

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Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

6 September 2017

1 reference

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

6 September 2017

1 reference

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

6 September 2017

1 reference

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Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

6 September 2017

1 reference

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Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

6 September 2017

1 reference

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

6 September 2017

1 reference

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

6 September 2017

1 reference

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Mice lacking HSP90beta fail to develop a placental labyrinth

6 September 2017

1 reference

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Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein

6 September 2017

1 reference

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Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

6 September 2017

1 reference

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The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

6 September 2017

1 reference

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

6 September 2017

1 reference

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

6 September 2017

1 reference

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Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

6 September 2017

1 reference

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Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice

6 September 2017

1 reference

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

6 September 2017

1 reference

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

6 September 2017

1 reference

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Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

6 September 2017

1 reference

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Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Identification of the von Hippel-Lindau disease tumor suppressor gene

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Identification of intragenic mutations in the von Hippel-Lindau disease tumour suppressor gene and correlation with disease phenotype

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Inhibition of transcription elongation by the VHL tumor suppressor protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Von Hippel-Lindau disease: a genetic study

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Clustering of features of von Hippel-Lindau syndrome: evidence for a complex genetic locus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Tumour suppression by the human von Hippel-Lindau gene product

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

HIF-2alpha specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Renal cell carcinoma risk in type 2 von Hippel-Lindau disease correlates with defects in pVHL stability and HIF-1alpha interactions.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Genotype-phenotype correlation in von Hippel-Lindau families with renal lesions.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Mouse placenta is a major hematopoietic organ.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Mutations in the VHL gene in sporadic apparently congenital polycythemia

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667565

Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: relationship to clinicopathological parameters

3 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.12

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.12

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.12

EIIaCre -- utility of a general deleter strain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.12

Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19252526

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2009.12

1 reference

18 August 2017

1 reference

18 August 2017

PubMed publication ID

19252526

1 reference