Role of E3 ubiquitin ligases in insulin resistance (Q38813011)

6 September 2017

title

Role of E3 ubiquitin ligases in insulin resistance (English)

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6 September 2017

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X-D Yang

1

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6 September 2017

D-X Xiang

series ordinal

2

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6 September 2017

Y-Y Yang

series ordinal

3

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6 September 2017

publication date

21 April 2016

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Diabetes, Obesity and Metabolism

6 September 2017

published in

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6 September 2017

volume

18

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6 September 2017

issue

8

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6 September 2017

page(s)

747-754

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6 September 2017

cites work

The metabolic syndrome

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The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

21 January 2018

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Insulin resistance and cardiovascular disease

21 January 2018

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New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

21 January 2018

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Tyrosine-specific protein kinase activity is associated with the purified insulin receptor

21 January 2018

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Tissue-specific roles of IRS proteins in insulin signaling and glucose transport

21 January 2018

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Critical nodes in signalling pathways: insights into insulin action

21 January 2018

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Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.

21 January 2018

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Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

21 January 2018

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Mechanisms underlying ubiquitination

21 January 2018

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MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling

21 January 2018

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Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake

21 January 2018

1 reference

Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling

21 January 2018

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SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

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Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice

21 January 2018

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Cbl-b is a critical regulator of macrophage activation associated with obesity-induced insulin resistance in mice.

21 January 2018

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The ubiquitin ligase Siah2 regulates obesity-induced adipose tissue inflammation

21 January 2018

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Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling

21 January 2018

1 reference

21 January 2018

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Ubiquitin ligases: cell-cycle control and cancer

21 January 2018

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RING domain E3 ubiquitin ligases

21 January 2018

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New insights into ubiquitin E3 ligase mechanism

21 January 2018

1 reference

21 January 2018

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Function and regulation of cullin-RING ubiquitin ligases

21 January 2018

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Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules

21 January 2018

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From mice to men: insights into the insulin resistance syndromes

21 January 2018

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Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

21 January 2018

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Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading.

21 January 2018

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Identification of the degradation determinants of insulin receptor substrate 1 for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination

21 January 2018

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The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation

21 January 2018

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The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling

21 January 2018

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

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Trim32 reduces PI3K-Akt-FoxO signaling in muscle atrophy by promoting plakoglobin-PI3K dissociation

21 January 2018

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Nedd4 haploinsufficient mice display moderate insulin resistance, enhanced lipolysis, and protection against high-fat diet-induced obesity

21 January 2018

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ITCH deficiency protects from diet-induced obesity.

21 January 2018

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The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance.

21 January 2018

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MG53 nucleates assembly of cell membrane repair machinery.

21 January 2018

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Mitsugumin 53 attenuates the activity of sarcoplasmic reticulum Ca(2+)-ATPase 1a (SERCA1a) in skeletal muscle

21 January 2018

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MG53 regulates membrane budding and exocytosis in muscle cells.

21 January 2018

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Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisome proliferation-activated receptor α.

21 January 2018

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TRIM72 negatively regulates myogenesis via targeting insulin receptor substrate-1.

21 January 2018

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Ubiquitin ligase Cbl-b and obesity-induced insulin resistance

21 January 2018

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

21 January 2018

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c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action

21 January 2018

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Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action

21 January 2018

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Casitas b-lineage lymphoma-deficient mice are protected against high-fat diet-induced obesity and insulin resistance

21 January 2018

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CBLB variants in type 1 diabetes and their genetic interaction with CTLA4.

21 January 2018

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Identification and functional analysis of CBLB mutations in type 1 diabetes

21 January 2018

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The cullin protein family

21 January 2018

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

21 January 2018

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SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice

21 January 2018

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Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance

21 January 2018

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Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation

21 January 2018

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Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

21 January 2018

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SCF and Cullin/Ring H2-based ubiquitin ligases

21 January 2018

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The SCF ubiquitin ligase: insights into a molecular machine

21 January 2018

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beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.

21 January 2018

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RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties

21 January 2018

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Nedd4 controls animal growth by regulating IGF-1 signaling

21 January 2018

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NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

21 January 2018

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Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc

21 January 2018

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Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity.

21 January 2018

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Macrophages, inflammation, and insulin resistance

21 January 2018

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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

21 January 2018

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Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

21 January 2018

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Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects

21 January 2018

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Inflammatory links between obesity and metabolic disease

21 January 2018

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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

21 January 2018

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The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

21 January 2018

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Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

21 January 2018

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Alternative Macrophage Activation and Metabolism

21 January 2018

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The roles of Pellino E3 ubiquitin ligases in immunity

21 January 2018

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Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity

21 January 2018

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Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression

21 January 2018

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Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

21 January 2018

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Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2

21 January 2018

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Estrogen down-regulation of the corepressor N-CoR: mechanism and implications for estrogen derepression of N-CoR-regulated genes

21 January 2018

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The ubiquitin ligase Siah2 regulates PPARγ activity in adipocytes.

21 January 2018

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PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

21 January 2018

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Strategies for the identification of ubiquitin ligase inhibitors

21 January 2018

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Suramin inhibits cullin-RING E3 ubiquitin ligases.

21 January 2018

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Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors

21 January 2018

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Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development

21 January 2018

1 reference

A Phase I First-in-Human Pharmacokinetic and Pharmacodynamic Study of Serdemetan in Patients with Advanced Solid Tumors

21 January 2018

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IRS-2 pathways integrate female reproduction and energy homeostasis

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/DOM.12677

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6 September 2017

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