Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis (Q38842714)

4 November 2017

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title

Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis (English)

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4 November 2017

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9

Rene S Kahn

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Christoph U Correll

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Roel A Ophoff

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John M Kane

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4 November 2017

Jian-Ping Zhang

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Todd Lencz

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Ryan X Zhang

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Masahiro Nitta

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Lawrence Maayan

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Majnu John

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Delbert G Robinson

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W Wolfgang Fleischhacker

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Anil K Malhotra

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4 November 2017

language of work or name

English

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publication date

23 May 2016

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4 November 2017

Schizophrenia Bulletin

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4 November 2017

42

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6

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4 November 2017

1418-1437

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Safety and tolerability of antipsychotic-mood stabilizer co-treatment in the management of acute bipolar disorder: results from a systematic review and exploratory meta-analysis

4 November 2017

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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Pharmacogenetics of antipsychotic-induced weight gain: review and clinical implications.

17 June 2018

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Risperidone-induced weight gain in referred children with autism spectrum disorders is associated with a common polymorphism in the 5-hydroxytryptamine 2C receptor gene

17 June 2018

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Antipsychotic drugs and obesity

17 June 2018

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Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain.

17 June 2018

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DRD2 promoter region variation predicts antipsychotic-induced weight gain in first episode schizophrenia

17 June 2018

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17 June 2018

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D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis

17 June 2018

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A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia

17 June 2018

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G-protein beta3 Subunit Gene 825C/T Polymorphism Is Not Associated with Olanzapine-Induced Weight Gain in Korean Schizophrenic Patients.

17 June 2018

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Absence of weight gain association with the HTR2C -759C/T polymorphism in patients with schizophrenia treated with iloperidone

17 June 2018

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Leptin gene -2548G/A variants predict risperidone-associated weight gain in children and adolescents

17 June 2018

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17 June 2018

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Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study

17 June 2018

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Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis

17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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Common variants near MC4R are associated with fat mass, weight and risk of obesity

17 June 2018

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Common genetic variation near MC4R is associated with waist circumference and insulin resistance

17 June 2018

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Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?

17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis

17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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Association of a human G-protein beta3 subunit variant with hypertension

17 June 2018

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Bias in meta-analysis detected by a simple, graphical test

17 June 2018

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RS-102221: A Novel High Affinity and Selective, 5-HT 2C Receptor Antagonist

17 June 2018

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A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia

17 June 2018

1 reference

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17 June 2018

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Serotonergic control of the organization of feeding and satiety

17 June 2018

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17 June 2018

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17 June 2018

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Fat mass- and obesity-associated (FTO) gene and antipsychotic-induced weight gain: an association study

17 June 2018

1 reference

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Methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism is associated with antipsychotic-induced weight gain in first-episode schizophrenia

22 August 2018

1 reference

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Association of the common MC4R rs17782313 polymorphism with antipsychotic-related weight gain

22 August 2018

1 reference

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Metabolic risk factors in first-episode schizophrenia: baseline prevalence and course analysed from the European First-Episode Schizophrenia Trial

22 August 2018

1 reference

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The obesity risk gene FTO influences body mass in chronic schizophrenia but not initial antipsychotic drug-induced weight gain in first-episode patients

22 August 2018

1 reference

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Pharmacogenomic associations with weight gain in olanzapine treatment of patients without schizophrenia

22 August 2018

1 reference

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The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain

22 August 2018

1 reference

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Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain

22 August 2018

1 reference

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Peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala: lack of association with weight gain in psychiatric inpatients treated with olanzapine or clozapine

22 August 2018

1 reference

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Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene

22 August 2018

1 reference

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TNF-α -308 G>A polymorphism and weight gain in patients with schizophrenia under long-term clozapine, risperidone or olanzapine treatment

22 August 2018

1 reference

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Association study of brain-derived neurotrophic factor gene polymorphisms and body weight change in schizophrenic patients under long-term atypical antipsychotic treatment

22 August 2018

1 reference

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Cannabinoid type 1 receptor gene polymorphisms are not associated with olanzapine-induced weight gain

22 August 2018

1 reference

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Polymorphisms of the HTR2C gene and antipsychotic-induced weight gain: an update and meta-analysis

22 August 2018

1 reference

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Effect of FTO, SH2B1, LEP, and LEPR polymorphisms on weight gain associated with antipsychotic treatment

22 August 2018

1 reference

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Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain

22 August 2018

1 reference

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Polymorphisms of the LEP- and LEPR genes, metabolic profile after prolonged clozapine administration and response to the antidiabetic metformin

22 August 2018

1 reference

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MTHFR genotype and differential evolution of metabolic parameters after initiation of a second generation antipsychotic: an observational study

22 August 2018

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Genetic association between TNF-alpha -308 G>A polymorphism and longitudinal weight change during clozapine treatment

22 August 2018

1 reference

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Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample.

22 August 2018

1 reference

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Dopamine receptor D2 gene is associated with weight gain in schizophrenic patients under long-term atypical antipsychotic treatment

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Association study of polymorphisms in insulin induced gene 2 (INSIG2) with antipsychotic-induced weight gain in European and African-American schizophrenia patients

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Association study of MDR1 and 5-HT2C genetic polymorphisms and antipsychotic-induced metabolic disturbances in female patients with schizophrenia.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Pharmacogenetics and olanzapine treatment: CYP1A2*1F and serotonergic polymorphisms influence therapeutic outcome.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

The association of olanzapine-induced weight gain with peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism in patients with schizophrenia.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Association of the alpha 2A adrenergic receptor -1291C/G polymorphism and antipsychotic-induced weight gain in European-Americans.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

C957T polymorphism of dopamine D2 receptor gene affects striatal DRD2 in vivo availability by changing the receptor affinity.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Association of antipsychotic induced weight gain and body mass index with GNB3 gene: a meta-analysis

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

-2548G/A functional polymorphism in the promoter region of leptin gene and antipsychotic agent-induced weight gain in schizophrenic patients: a study of nuclear family-based association

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Association of HTR2C-759C/T and -697G/C polymorphisms with antipsychotic agent-induced weight gain

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

DRD4 48 bp VNTR but not 5-HT 2C Cys23Ser receptor polymorphism is related to antipsychotic-induced weight gain

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Lack of association between the -759C/T polymorphism of the 5-HT2C receptor gene and olanzapine-induced weight gain among Korean schizophrenic patients

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

SNAP-25 gene polymorphisms and weight gain in schizophrenic patients

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Correlation between body mass index and striatal dopamine transporter availability in healthy volunteers--a SPECT study

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

-759 C/T polymorphism of 5-HT2C receptor gene and early phase weight gain associated with antipsychotic drug treatment

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

The relationship between P-glycoprotein (PGP) polymorphisms and response to olanzapine treatment in schizophrenia

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Weight gain associated with the alpha2a-adrenergic receptor -1,291 C/G polymorphism and olanzapine treatment

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

C825T polymorphism in the human G protein beta3 subunit gene is associated with long-term clozapine treatment-induced body weight change in the Chinese population

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Polymorphism of the adrenergic receptor alpha 2a -1291C>G genetic variation and clozapine-induced weight gain

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Weight gain associated with the -759C/T polymorphism of the 5HT2C receptor and olanzapine

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Clozapine-induced weight gain associated with the 5HT2C receptor -759C/T polymorphism

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Lack of association between the -759C/T polymorphism of the 5-HT2C receptor gene and clozapine-induced weight gain among German schizophrenic individuals

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Association study of adrenergic beta3 receptor (Trp64Arg) and G-protein beta3 subunit gene (C825T) polymorphisms and weight change during clozapine treatment

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Association of -2548G/A functional polymorphism in the promoter region of leptin gene with antipsychotic agent-induced weight gain

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

No association of tumor necrosis factor alpha gene polymorphisms with schizophrenia or response to clozapine

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Oral administration of the 5-HT2Creceptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Polymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene and clozapine-induced weight gain

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

No association of antipsychotic agent-induced weight gain with a DA receptor gene polymorphism and therapeutic response.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

759C/T genetic variation of 5HT(2C) receptor and clozapine-induced weight gain

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

-759C/T genetic variation of 5HT(2C) receptor and clozapine-induced weight gain

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Genetic variants of the serotonin system and weight change during clozapine treatment

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5049532

Common nonsynonymous variants in PCSK1 confer risk of obesity

22 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FSCHBUL%2FSBW058

Randomized comparison of olanzapine versus risperidone for the treatment of first-episode schizophrenia: 4-month outcomes

21 January 2018

1 reference

12 December 2020

Leptin and leptin receptor gene polymorphisms and increases in body mass index (BMI) from olanzapine treatment in persons with schizophrenia

1 reference

12 December 2020

Identification of polymorphic loci in the promoter region of the serotonin 5-HT2C receptor gene and their association with obesity and type II diabetes

1 reference

12 December 2020

Pharmacogenetics of antipsychotic-induced weight gain

1 reference

12 December 2020

Identifiers

DOI

10.1093/SCHBUL/SBW058

1 reference

release_n3ksxj2m4bdc7difc3vce7cwa4

4 November 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/n3ksxj2m4bdc7difc3vce7cwa4

24 November 2022

mapped directly with Wikidata item

1 reference

4 November 2017

PubMed publication ID

27217270

1 reference