Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13 (Q35557102)

8 August 2017

1 reference

title

Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13 (English)

1 reference

8 August 2017

Tohru Kozasa

1

1 reference

8 August 2017

Nicole Hajicek

series ordinal

2

1 reference

8 August 2017

Christina R Chow

series ordinal

3

1 reference

8 August 2017

Nobuchika Suzuki

series ordinal

4

1 reference

8 August 2017

publication date

26 August 2011

1 reference

8 August 2017

published in

Journal of Biochemistry

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8 August 2017

volume

150

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8 August 2017

issue

4

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8 August 2017

page(s)

357-369

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The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement

8 August 2017

cites work

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Identification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex

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Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation

12 July 2018

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Activated RhoA Binds to the Pleckstrin Homology (PH) Domain of PDZ-RhoGEF, a Potential Site for Autoregulation

12 July 2018

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12 July 2018

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12 July 2018

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LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer

12 July 2018

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The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA.

12 July 2018

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A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.

12 July 2018

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12 July 2018

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Recognition of the Activated States of Gα13 by the rgRGS Domain of PDZRhoGEF

12 July 2018

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A quantitative atlas of mitotic phosphorylation

12 July 2018

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G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension

12 July 2018

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Structural basis of effector regulation and signal termination in heterotrimeric Galpha proteins

12 July 2018

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Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

12 July 2018

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Distinct regions of Galpha13 participate in its regulatory interactions with RGS homology domain-containing RhoGEFs

12 July 2018

1 reference

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Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils

12 July 2018

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Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)

12 July 2018

1 reference

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Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho

12 July 2018

1 reference

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Receptors coupled to heterotrimeric G proteins of the G12 family

12 July 2018

1 reference

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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

12 July 2018

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The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle

12 July 2018

1 reference

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Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13.

12 July 2018

1 reference

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Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor

12 July 2018

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Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential

12 July 2018

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Identification and molecular characterization of the G alpha12-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans

12 July 2018

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Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor

12 July 2018

1 reference

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Protein Kinase Cα-Induced p115RhoGEF Phosphorylation Signals Endothelial Cytoskeletal Rearrangement

12 July 2018

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12 July 2018

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Hyperactivation of the G12-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via protein kinase C.

12 July 2018

1 reference

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12 July 2018

RHO-GTPases and cancer

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Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF

12 July 2018

1 reference

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Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

12 July 2018

1 reference

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Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.

12 July 2018

1 reference

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Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors

12 July 2018

1 reference

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The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG

12 July 2018

1 reference

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Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF

12 July 2018

1 reference

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Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology

12 July 2018

1 reference

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Hsp90 interactions and acylation target the G protein Galpha 12 but not Galpha 13 to lipid rafts

12 July 2018

1 reference

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Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

12 July 2018

1 reference

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The role of Rho GTPases in disease development

12 July 2018

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Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase

12 July 2018

1 reference

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Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF

12 July 2018

1 reference

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Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases

12 July 2018

1 reference

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Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor

12 July 2018

1 reference

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In vivo functions of heterotrimeric G-proteins: studies in Galpha-deficient mice.

12 July 2018

1 reference

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Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins

12 July 2018

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Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho

12 July 2018

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GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins

12 July 2018

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Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation.

12 July 2018

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Functions of a rho-specific guanine nucleotide exchange factor in neurite retraction. Possible role of a proline-rich motif of KIAA0380 in localization

12 July 2018

1 reference

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Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding

12 July 2018

1 reference

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Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

12 July 2018

1 reference

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Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF

12 July 2018

1 reference

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Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member

12 July 2018

1 reference

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Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction

12 July 2018

1 reference

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A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

12 July 2018

1 reference

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The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain

12 July 2018

1 reference

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Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13

12 July 2018

1 reference

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Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha12/13

12 July 2018

1 reference

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Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets

12 July 2018

1 reference

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Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

12 July 2018

1 reference

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p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

12 July 2018

1 reference

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Galpha12 requires acylation for its transforming activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Rho GTPases and the actin cytoskeleton

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila

12 July 2018

1 reference

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The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation

12 July 2018

1 reference

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Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro

12 July 2018

1 reference

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Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Galpha12 and galpha13 are phosphorylated during platelet activation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Protein kinase C phosphorylates G12 alpha and inhibits its interaction with G beta gamma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Mutant alpha subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Purification and characterization of the alpha subunit of G13.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

The ras gene family and human carcinogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Structure and function of signal-transducing GTP-binding proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Diversity of G proteins in signal transduction

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Loss of Lsc/p115 protein leads to neuronal hypoplasia in the esophagus and an achalasia-like phenotype in mice

12 July 2018

1 reference

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The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.

26 September 2018

1 reference

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Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated rho Guanine-nucleotide exchange factor.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Lsc regulates marginal-zone B cell migration and adhesion and is required for the IgM T-dependent antibody response.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Signal-crosstalk between Rho/ROCK and c-Jun NH2-terminal kinase mediates migration of vascular smooth muscle cells stimulated by angiotensin II.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

The Lsc RhoGEF mediates signaling from thromboxane A2 to actin polymerization and apoptosis in thymocytes

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Regulation of the extracellular signal-regulated kinase pathway in adult myocardium: differential roles of G(q/11), Gi and G(12/13) proteins in signalling by alpha1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Mechanisms for reversible regulation between G13 and Rho exchange factors

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Role for G(12)/G(13) in agonist-induced vascular smooth muscle cell contraction.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

The G-protein G13 but not G12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218643

Purification of Recombinant G Proteins from Sf9 Cells by Hexahistidine Tagging of Associated Subunits

26 September 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVR105

Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVR105

Structure of the RGS-like Domain from PDZ-RhoGEF

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVR105

The significance of DNA and protein adducts in human biomonitoring studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVR105

Constitutively active Galpha12, Galpha13, and Galphaq induce Rho-dependent neurite retraction through different signaling pathways

21 January 2018

1 reference

12 December 2020

Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator

1 reference

12 December 2020

The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF

1 reference

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1093/JB/MVR105

1 reference

8 August 2017

1 reference

8 August 2017

1 reference