Melanin and neuromelanin binding of drugs and chemicals: toxicological implications (Q38867426)

7 September 2017

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title

Melanin and neuromelanin binding of drugs and chemicals: toxicological implications (English)

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7 September 2017

Oskar Karlsson

1

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7 September 2017

Nils Gunnar Lindquist

series ordinal

2

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7 September 2017

publication date

16 June 2016

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7 September 2017

published in

Archives of Toxicology

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7 September 2017

volume

90

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7 September 2017

issue

8

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7 September 2017

page(s)

1883-1891

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Applications of affinity chromatography to the study of drug-melanin binding interactions

7 September 2017

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A retinopathy on Guam with high prevalence in Lytico-Bodig

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Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain

21 January 2018

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Selectivity of the parkinsonian neurotoxin MPTP: toxic metabolite MPP+ binds to neuromelanin

21 January 2018

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Evidence for neuromelanin involvement in MPTP-induced neurotoxicity

21 January 2018

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Retinal pigment epithelium melanin and ocular toxicity

21 January 2018

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Epidemiology of Parkinson's disease

21 January 2018

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Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment

21 January 2018

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Influence of neuromelanin on oxidative pathways within the human substantia nigra

21 January 2018

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Iron-binding characteristics of neuromelanin of the human substantia nigra.

21 January 2018

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Anti-melanin antibodies are increased in sera in Parkinson's disease

21 January 2018

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Neuromelanins of human brain have soluble and insoluble components with dolichols attached to the melanic structure

21 January 2018

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Studies on neuromelanin: II. Melanin in the brainstems of infants and children

21 January 2018

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Molecular mechanisms of pesticide-induced neurotoxicity: Relevance to Parkinson's disease

21 January 2018

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Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease

21 January 2018

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Family history of melanoma and Parkinson disease risk

21 January 2018

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Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.

21 January 2018

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Evidence for specific phases in the development of human neuromelanin.

21 January 2018

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Pigmentation genes link Parkinson's disease to melanoma, opening a window on both etiologies

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Role of ocular melanin in ophthalmic physiology and pathology

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Clinical and neuropathological aspects of autosomal recessive juvenile parkinsonism

21 January 2018

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The IFPCS presidential lecture: a chemist's view of melanogenesis

21 January 2018

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Chemistry of mixed melanogenesis--pivotal roles of dopaquinone

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Melanin affinity and its possible role in neurodegeneration

21 January 2018

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Retention of the cyanobacterial neurotoxin beta-N-methylamino-l-alanine in melanin and neuromelanin-containing cells--a possible link between Parkinson-dementia complex and pigmentary retinopathy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Chloroquine retinopathy: lipofuscin- and melanin-related fundus autofluorescence, optical coherence tomography and multifocal electroretinography

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Value of the concept of minimal detectable dosage in human hair

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

The parkinsonian models: invertebrates to mammals

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

MPTP toxicity: implications for research in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Autoimmunity, dendritic cells and relevance for Parkinson's disease

21 January 2018

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Interaction between chemicals and melanin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Studies on the mechanism of drug-binding to melanin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Binding of drugs to eye melanin is not predictive of ocular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Neuromelanin enhances the toxicity of α-synuclein in SK-N-SH cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Inverse relationship between the contents of neuromelanin pigment and the vesicular monoamine transporter-2: human midbrain dopamine neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Neuromelanin and its possible protective and destructive properties

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Meta-analysis of the relationship between Parkinson disease and melanoma

21 January 2018

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A novel aliphatic 18F-labeled probe for PET imaging of melanoma

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Interpretation of Ocular Melanin Drug Binding Assays. Alternatives to the Model of Multiple Classes of Independent Sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Pheomelanin as a binding site for drugs and chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Parkinson's disease-related protein, alpha-synuclein, in malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Aging of the nigrostriatal system in the squirrel monkey

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

An overview on the toxic morphological changes in the retinal pigment epithelium after systemic compound administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Neuromelanin is an immune stimulator for dendritic cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Long-term retention of neurotoxic beta-carbolines in brain neuromelanin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

The role of alpha-synuclein in melanin synthesis in melanoma and dopaminergic neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

A comparison of 3H-cocaine binding on melanin granules and human hair in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

A cohort study of amyotrophic lateral sclerosis and parkinsonism-dementia on Guam and Rota

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Properties and function of the ocular melanin--a photobiophysical view

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Neurochemical findings in the MPTP model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Chloroquine and hydroxychloroquine binding to melanin: Some possible consequences for pathologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Protective and toxic roles of dopamine in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Neuromelanin inhibits enzymatic activity of 26S proteasome in human dopaminergic SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Current challenges in understanding melanogenesis: bridging chemistry, biological control, morphology, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Melanins: Skin Pigments and Much More—Types, Structural Models, Biological Functions, and Formation Routes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

The ALS/PDC syndrome of Guam and the cycad hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Parkinson disease in twins: an etiologic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Ocular toxicity due to chloroquine and hydroxychloroquine: electrophysiological and visual function correlates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

The structure of neuromelanin as studied by chemical degradative methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Characterization of melanin in human iridal and choroidal melanocytes from eyes with various colored irides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Complete ascertainment of Parkinson disease in the Swedish Twin Registry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Human neuromelanin: an endogenous microglial activator for dopaminergic neuron death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Engineering Melanin Nanoparticles as an Efficient Drug-Delivery System for Imaging-Guided Chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1757-0

10.1007/S00204-016-1757-0

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

7 September 2017

1022533158

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1 reference