Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin. (Q38878268)

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scientific article published on May 2015

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English	Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin.	scientific article published on May 2015

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7 March 2020

Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin (English)

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7 March 2020

peritoneal mesothelioma

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Valentina Doldi

3

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7 March 2020

Marcello Deraco

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7 March 2020

Paolo Gandellini

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7 March 2020

Nadia Zaffaroni

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7 March 2020

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Michelandrea De Cesare

1

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7 March 2020

Denis Cominetti

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7 March 2020

Alessia Lopergolo

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7 March 2020

Sharon Friedlander

7

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7 March 2020

Yosef Landesman

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7 March 2020

Michael G Kauffman

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7 March 2020

Sharon Shacham

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7 March 2020

Marzia Pennati

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7 March 2020

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1 May 2015

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7 March 2020

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7 March 2020

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7 March 2020

15

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7 March 2020

13119-13132

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7 March 2020

Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents

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9 September 2017

SINE (selective inhibitor of nuclear export)--translational science in a new class of anti-cancer agents

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9 September 2017

Novel small molecule XPO1/CRM1 inhibitors induce nuclear accumulation of TP53, phosphorylated MAPK and apoptosis in human melanoma cells

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9 September 2017

KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma

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9 September 2017

Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer

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9 September 2017

KPT-330 has antitumour activity against non-small cell lung cancer

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9 September 2017

Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma

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9 September 2017

XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer

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9 September 2017

Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.

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9 September 2017

Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias

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9 September 2017

CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications.

1 reference

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9 September 2017

Prognostic impact and targeting of CRM1 in acute myeloid leukemia

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9 September 2017

Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537003

9 September 2017

Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537003

9 September 2017

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537003

9 September 2017

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells

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9 September 2017

Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia

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9 September 2017

Targeting survivin in cancer

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9 September 2017

Nuclear export of proteins and drug resistance in cancer

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9 September 2017

Diffuse malignant peritoneal mesothelioma--an update on treatment

1 reference

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9 September 2017

Protein localization in disease and therapy.

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9 September 2017

Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537003

9 September 2017

Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential

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9 September 2017

Advances in malignant mesothelioma

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9 September 2017

Surfing the p53 network

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9 September 2017

Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

1 reference

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9 September 2017

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

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9 September 2017

Phase I trial of elactocin

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9 September 2017

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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9 September 2017

CRM1 and BRAF inhibition synergize and induce tumor regression in BRAF-mutant melanoma

1 reference

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9 September 2017

CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537003

9 September 2017

Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537003

9 September 2017

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

1 reference

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14 September 2017

The CRM1 nuclear export protein in normal development and disease.

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17 June 2018

The expression of CRM1 is associated with prognosis in human osteosarcoma

1 reference

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17 June 2018

In vitro pharmacodynamics of 1-beta-D-arabinofuranosylcytosine: synergy of antitumor activity with cis-diamminedichloroplatinum(II).

1 reference

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17 June 2018

Diffuse malignant peritoneal mesothelioma: long-term survival with complete cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC).

1 reference

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22 August 2018

The role of perioperative systemic chemotherapy in diffuse malignant peritoneal mesothelioma patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

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22 August 2018

Survivin withdrawal by nuclear export failure as a physiological switch to commit cells to apoptosis.

1 reference

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22 August 2018

Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis.

1 reference

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22 August 2018

The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.

1 reference

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22 August 2018

Diffuse malignant peritoneal mesothelioma: Failure analysis following cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC).

1 reference

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22 August 2018

Survivin is highly expressed and promotes cell survival in malignant peritoneal mesothelioma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537003

22 August 2018

CRM1-mediated nuclear export determines the cytoplasmic localization of the antiapoptotic protein Survivin

1 reference

https://pubmed.ncbi.nlm.nih.gov/25948791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic value of CRM1 in pancreas cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25948791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.18632/ONCOTARGET.3761

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Europe PubMed Central

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7 March 2020

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7 March 2020

PubMed publication ID

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Europe PubMed Central

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7 March 2020

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