Bortezomib inhibits expression of TGF-β1, IL-10, and CXCR4, resulting in decreased survival and migration of cutaneous T cell lymphoma cells (Q38909786)

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English	Bortezomib inhibits expression of TGF-β1, IL-10, and CXCR4, resulting in decreased survival and migration of cutaneous T cell lymphoma cells	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

Bortezomib inhibits expression of TGF-β1, IL-10, and CXCR4, resulting in decreased survival and migration of cutaneous T cell lymphoma cells (English)

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

cutaneous T cell lymphoma

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Tzu-Pei Chang

1

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

Vladimir Poltoratsky

2

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

Ivana Vancurova

3

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

language of work or name

0 references

publication date

13 February 2015

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

Journal of Immunology

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Europe PubMed Central

PMC publication ID

7 September 2017

194

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

6

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

2942-2953

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

The regulation of IL-10 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355060

9 September 2017

Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers

1 reference

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Proteasome inhibition increases recruitment of IκB kinase β (IKKβ), S536P-p65, and transcription factor EGR1 to interleukin-8 (IL-8) promoter, resulting in increased IL-8 production in ovarian cancer cells

1 reference

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Regulatory T cell subsets in human cancer: are they regulating for or against tumor progression?

1 reference

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9 September 2017

Lessons learned from gene expression profiling of cutaneous T-cell lymphoma

1 reference

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9 September 2017

Proteasome inhibition by bortezomib increases IL-8 expression in androgen-independent prostate cancer cells: the role of IKKα.

1 reference

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Beyond TGFβ: roles of other TGFβ superfamily members in cancer

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Management of cutaneous T cell lymphoma: new and emerging targets and treatment options

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Dimer-specific regulatory mechanisms within the NF-κB family of transcription factors

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9 September 2017

Cutaneous T-cell lymphomas: a review of new discoveries and treatments

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The role of cytokine signaling in the pathogenesis of cutaneous T-cell lymphoma

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miR-122 regulates p53/Akt signalling and the chemotherapy-induced apoptosis in cutaneous T-cell lymphoma

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A noncanonical Flt3ITD/NF-κB signaling pathway represses DAPK1 in acute myeloid leukemia

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Cutaneous T-cell lymphoma: 2011 update on diagnosis, risk-stratification, and management

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9 September 2017

Regulatory T cells and immunodeficiency in mycosis fungoides and Sézary syndrome.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355060

9 September 2017

Evolving insights in the pathogenesis and therapy of cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome)

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355060

9 September 2017

Sézary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-beta on the cell surface

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9 September 2017

Bortezomib induces nuclear translocation of IκBα resulting in gene-specific suppression of NF-κB--dependent transcription and induction of apoptosis in CTCL.

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9 September 2017

A single NFκB system for both canonical and non-canonical signaling

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Cellular and molecular basis for the regulation of inflammation by TGF-beta

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9 September 2017

The regulation of IL-10 production by immune cells

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9 September 2017

The nuclear signaling of NF-kappaB: current knowledge, new insights, and future perspectives

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355060

9 September 2017

Proteasome inhibitors in the treatment of multiple myeloma

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9 September 2017

Cutaneous T-cell lymphoma: roles for chemokines and chemokine receptors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355060

9 September 2017

Interleukin-10: new perspectives on an old cytokine

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355060

9 September 2017

CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.

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9 September 2017

Novel therapies for cutaneous T-cell lymphomas

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355060

9 September 2017

Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes.

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9 September 2017

Phase II trial of proteasome inhibitor bortezomib in patients with relapsed or refractory cutaneous T-cell lymphoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355060

9 September 2017

Transcriptional regulation via the NF-kappaB signaling module.

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NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355060

9 September 2017

The spectrum of cutaneous T-cell lymphomas: new insights into biology and therapy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355060

9 September 2017

Immunopathogenesis and therapy of cutaneous T cell lymphoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355060

9 September 2017

The life cycle of cutaneous T cell lymphoma reveals opportunities for targeted drug therapy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355060

9 September 2017

Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sézary syndrome identified by gene expression analysis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355060

9 September 2017

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

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9 September 2017

p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1.

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9 September 2017

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

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Lymphocyte traffic control by chemokines

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Proteasome inhibitors: a novel class of potent and effective antitumor agents.

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9 September 2017

Reduced surface expression of transforming growth factor beta receptor type II in mitogen-activated T cells from Sézary patients

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9 September 2017

Cellular proliferation and activation of NF kappa B are induced by autocrine production of tumor necrosis factor alpha in the human T lymphoma line HuT 78.

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9 September 2017

Distinct combinations of NF-kappa B subunits determine the specificity of transcriptional activation

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9 September 2017

Proteasome inhibition as a novel mechanism of the proapoptotic activity of γ-secretase inhibitor I in cutaneous T-cell lymphoma.

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9 September 2017

Bortezomib in combination with CHOP as first-line treatment for patients with stage III/IV peripheral T-cell lymphomas: a multicentre, single-arm, phase 2 trial

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14 September 2017

Reduced CXCR4 expression is associated with extramedullary disease in a mouse model of myeloma and predicts poor survival in multiple myeloma patients treated with bortezomib

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Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in cutaneous T cell lymphoma

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14 September 2017

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Down-regulating constitutive activation of the NF-kappaB canonical pathway overcomes the resistance of cutaneous T-cell lymphoma to apoptosis.

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A dominant inhibitory mutant of the type II transforming growth factor beta receptor in the malignant progression of a cutaneous T-cell lymphoma

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14 September 2017

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25 September 2017

Activation of the interleukin-10 gene in the human T lymphoma line HuT 78: identification and characterization of NF-kappa B binding sites in the regulatory region of the interleukin-10 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355060

25 September 2017

Rearranged NFKB2 gene in the HUT78 T-lymphoma cell line codes for a constitutively nuclear factor lacking transcriptional repressor functions.

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Autocrine regulation of the transcription factor NF kappa B by TNF alpha in the human T cell lymphoma line Hut 78.

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Bcl3 regulates pro-survival and pro-inflammatory gene expression in cutaneous T-cell lymphoma

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17 June 2018

Immune function abnormalities in peripheral blood mononuclear cell cytokine expression differentiates stages of cutaneous T-cell lymphoma/mycosis fungoides

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NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription

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Analysis of TGFβ1 and IL-10 transcriptional regulation in CTCL cells by chromatin immunoprecipitation.

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22 August 2018

A role for regulatory T cells in cutaneous T-Cell lymphoma; induction of a CD4 + CD25 + Foxp3+ T-cell phenotype associated with HTLV-1 infection.

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22 August 2018

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22 August 2018

Two pathways to NF-kappaB.

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22 August 2018

Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells

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4 November 2018

Expression dynamics of CXCL12 and CXCR4 during the progression of mycosis fungoides

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12 December 2020

based on heuristic

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Mechanism of expression and role in transcriptional control of the proto-oncogene NFKB-2/LYT-10

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https://pubmed.ncbi.nlm.nih.gov/25681335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates

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12 December 2020

based on heuristic

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TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules

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https://pubmed.ncbi.nlm.nih.gov/25681335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.1402610

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

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