EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications. (Q38912207)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25659577%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications (English)

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29 February 2020

1

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29 February 2020

Jacqueline F Donoghue

2

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29 February 2020

Timothy E Adams

8

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29 February 2020

Terrance G Johns

9

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29 February 2020

author name string

M Van Sinderen

3

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29 February 2020

V Dubljevic

4

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29 February 2020

S Budiman

5

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29 February 2020

M Devlin

6

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29 February 2020

I Street

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29 February 2020

language of work or name

English

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publication date

9 February 2015

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29 February 2020

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29 February 2020

volume

34

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issue

41

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29 February 2020

page(s)

5277-5287

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Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

29 February 2020

cites work

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

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The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered

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Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation

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EGFRvIII gene rearrangement is an early event in glioblastoma tumorigenesis and expression defines a hierarchy modulated by epigenetic mechanisms.

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The EGFRvIII variant in glioblastoma multiforme

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EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma

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Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases

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Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies

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Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

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The plasticity of oncogene addiction: implications for targeted therapies directed to receptor tyrosine kinases

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De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients

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Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors

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The effect of epidermal growth factor receptor variant III on glioma cell migration by stimulating ERK phosphorylation through the focal adhesion kinase signaling pathway

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Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis

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AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts

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In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation

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microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma

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MicroRNA-7 inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via targeting FAK expression

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Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in human gliomas is associated with unfavorable overall survival

21 January 2018

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Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition

21 January 2018

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The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells

21 January 2018

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Signaling networks assembled by oncogenic EGFR and c-Met

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EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes

21 January 2018

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EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma

21 January 2018

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

21 January 2018

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Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02

21 January 2018

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Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

21 January 2018

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A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation.

21 January 2018

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Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.

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Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo

21 January 2018

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Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET.

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Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene

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The Efficacy of Epidermal Growth Factor Receptor-Specific Antibodies against Glioma Xenografts Is Influenced by Receptor Levels, Activation Status, and Heterodimerization

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A simple guide screw method for intracranial xenograft studies in mice

31 March 2020

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25659577

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2014.448

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25659577%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

29 February 2020

1016926114

0 references

1 reference

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