Melatonin influences somatostatin secretion from human pancreatic δ-cells via MT1 and MT2 receptors (Q38920395)

7 September 2017

Melatonin influences somatostatin secretion from human pancreatic δ-cells via MT1 and MT2 receptors (English)

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7 September 2017

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Juliane Zibolka

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PubMed ID

25585597

7 September 2017

Eckhard Mühlbauer

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2

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PubMed ID

25585597

7 September 2017

Elmar Peschke

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3

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7 September 2017

27 January 2015

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Journal of Pineal Research

7 September 2017

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7 September 2017

58

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7 September 2017

2

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7 September 2017

198-209

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Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans

7 September 2017

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Pancreatic islet cells: a model for calcium-dependent peptide release

21 January 2018

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Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy

21 January 2018

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Pancreas islets in metabolic signaling--focus on the beta-cell

21 January 2018

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An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice

21 January 2018

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Autonomous and self-sustained circadian oscillators displayed in human islet cells

21 January 2018

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Clock genes and metabolic disease

21 January 2018

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Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling

21 January 2018

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Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1.

21 January 2018

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Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

21 January 2018

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Function and expression of melatonin receptors on human pancreatic islets

21 January 2018

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Influence of melatonin and serotonin on glucose-stimulated insulin release from perifused rat pancreatic islets in vitro

21 January 2018

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Melatonin inhibits insulin secretion in rat insulinoma β-cells (INS-1) heterologously expressing the human melatonin receptor isoform MT2.

21 January 2018

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Melatonin influences insulin secretion primarily via MT(1) receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets

21 January 2018

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Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells

21 January 2018

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Modulation of the cGMP signaling pathway by melatonin in pancreatic beta-cells

21 January 2018

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Melatonin stimulates glucagon secretion in vitro and in vivo

21 January 2018

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Evidence of the receptor-mediated influence of melatonin on pancreatic glucagon secretion via the Gαq protein-coupled and PI3K signaling pathways

21 January 2018

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Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function

21 January 2018

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A role for islet somatostatin in mediating sympathetic regulation of glucagon secretion

21 January 2018

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Glucose generates coincident insulin and somatostatin pulses and antisynchronous glucagon pulses from human pancreatic islets

21 January 2018

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Apomorphine is a bimodal modulator of TRPA1 channels

21 January 2018

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Loss of melatonin signalling and its impact on circadian rhythms in mouse organs regulating blood glucose

21 January 2018

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A new mathematical model for relative quantification in real-time RT-PCR

21 January 2018

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Somatostatin actions via somatostatin receptors on the ocular surface are modulated by inflammatory processes

21 January 2018

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R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion

21 January 2018

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Melatonin MT₁ and MT₂ receptors display different molecular pharmacologies only in the G-protein coupled state.

21 January 2018

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Melatonin inhibits insulin secretion and decreases PKA levels without interfering with glucose metabolism in rat pancreatic islets.

21 January 2018

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International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors

21 January 2018

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Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes

21 January 2018

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SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells

21 January 2018

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Integration of ATP, cAMP, and Ca2+ signals in insulin granule exocytosis

21 January 2018

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Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

21 January 2018

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Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1.

21 January 2018

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cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37)

21 January 2018

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A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1.

21 January 2018

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Cyclic nucleotide phosphodiesterases in pancreatic islets

21 January 2018

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Exocytotic properties of human pancreatic beta-cells

21 January 2018

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Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

21 January 2018

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Dual coupling of MT(1) and MT(2) melatonin receptors to cyclic AMP and phosphoinositide signal transduction cascades and their regulation following melatonin exposure.

21 January 2018

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Parallel signaling pathways of melatonin in the pancreatic beta-cell

21 January 2018

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Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.

21 January 2018

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Homologous and heterologous asynchronicity between identified alpha-, beta- and delta-cells within intact islets of Langerhans in the mouse

21 January 2018

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Daily rhythm of glucose-induced insulin secretion by isolated islets from intact and pinealectomized rat.

21 January 2018

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Short-term exposure to melatonin differentially affects the functional sensitivity and trafficking of the hMT1 and hMT2 melatonin receptors

21 January 2018

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MT1 melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation

21 January 2018

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Melatonin synthesis impairment as a new deleterious outcome of diabetes-derived hyperglycemia.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JPI.12206

1 reference

7 September 2017

1 reference

PubMed ID

25585597