Melatonin influences somatostatin secretion from human pancreatic δ-cells via MT1 and MT2 receptors (Q38920395)

7 September 2017

title

Melatonin influences somatostatin secretion from human pancreatic δ-cells via MT1 and MT2 receptors (English)

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7 September 2017

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Juliane Zibolka

1

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7 September 2017

Eckhard Mühlbauer

series ordinal

2

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7 September 2017

Elmar Peschke

series ordinal

3

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7 September 2017

publication date

27 January 2015

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Journal of Pineal Research

7 September 2017

published in

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7 September 2017

volume

58

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7 September 2017

issue

2

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7 September 2017

page(s)

198-209

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Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans

7 September 2017

cites work

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Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

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Melatonin inhibits insulin secretion in rat insulinoma β-cells (INS-1) heterologously expressing the human melatonin receptor isoform MT2.

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Melatonin influences insulin secretion primarily via MT(1) receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets

21 January 2018

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Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells

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Modulation of the cGMP signaling pathway by melatonin in pancreatic beta-cells

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Melatonin stimulates glucagon secretion in vitro and in vivo

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Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function

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A role for islet somatostatin in mediating sympathetic regulation of glucagon secretion

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Glucose generates coincident insulin and somatostatin pulses and antisynchronous glucagon pulses from human pancreatic islets

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Somatostatin actions via somatostatin receptors on the ocular surface are modulated by inflammatory processes

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R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion

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Melatonin MT₁ and MT₂ receptors display different molecular pharmacologies only in the G-protein coupled state.

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21 January 2018

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21 January 2018

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21 January 2018

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Short-term exposure to melatonin differentially affects the functional sensitivity and trafficking of the hMT1 and hMT2 melatonin receptors

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MT1 melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation

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Melatonin synthesis impairment as a new deleterious outcome of diabetes-derived hyperglycemia.

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21 January 2018

Identifiers

DOI

10.1111/JPI.12206

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7 September 2017

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