A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion (Q38961595)

8 September 2017

A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion (English)

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8 September 2017

Vijay Pralhad Kale

1

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8 September 2017

Jeremy A Hengst

2

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8 September 2017

Dhimant H Desai

3

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8 September 2017

Taryn E Dick

4

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8 September 2017

Katherine N Choe

5

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8 September 2017

Ashley L Colledge

6

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8 September 2017

Yoshinori Takahashi

7

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8 September 2017

Shen-Shu Sung

8

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8 September 2017

Shantu G Amin

9

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8 September 2017

Jong K Yun

10

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8 September 2017

language of work or name

English

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publication date

27 August 2014

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8 September 2017

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354

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2

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8 September 2017

299-310

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describes a project that uses

8 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4182185/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Regulation of ROCK activity in cancer

9 September 2017

1 reference

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Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

9 September 2017

1 reference

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ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion

9 September 2017

1 reference

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RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer

9 September 2017

1 reference

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Cancer invasion and the microenvironment: plasticity and reciprocity

9 September 2017

1 reference

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Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion

9 September 2017

1 reference

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Hallmarks of Cancer: The Next Generation

9 September 2017

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Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

9 September 2017

1 reference

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Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity

9 September 2017

1 reference

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Non-muscle myosin II takes centre stage in cell adhesion and migration

9 September 2017

1 reference

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Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

9 September 2017

1 reference

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Rho kinase (ROCK) inhibitors

9 September 2017

1 reference

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The Rho kinases I and II regulate different aspects of myosin II activity

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion

9 September 2017

1 reference

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PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation

9 September 2017

1 reference

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Myosin phosphatase: structure, regulation and function

9 September 2017

1 reference

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Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

Rocks: multifunctional kinases in cell behaviour

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters

9 September 2017

1 reference

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Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

9 September 2017

1 reference

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Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells

9 September 2017

1 reference

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p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

Effect of fasudil on growth, adhesion, invasion, and migration of 95D lung carcinoma cells in vitro

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

Pharmacological inhibition of Rho-kinase signaling with Y-27632 blocks melanoma tumor growth.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

Rho-kinase dependent organization of stress fibers and focal adhesions in cultured fibroblasts.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

Effect of Wf-536, a novel ROCK inhibitor, against metastasis of B16 melanoma

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

Possible role of the RhoC/ROCK pathway in progression of clear cell renal cell carcinoma.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

The rho/rho-kinase pathway is involved in the progression of testicular germ cell tumour.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

Y-27632, an inhibitor of rho-associated protein kinase, suppresses tumor cell invasion via regulation of focal adhesion and focal adhesion kinase.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

Rho GTPases are over-expressed in human tumors.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182185

Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25172415

12 December 2020

inferred from PubMed ID database lookup

Overexpression of RhoA mRNA is associated with advanced stage in testicular germ cell tumour

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25172415

12 December 2020

inferred from PubMed ID database lookup

Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25172415

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.CANLET.2014.08.032

1 reference

8 September 2017

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8 September 2017

1 reference