Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition. (Q38991113)

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19 March 2020

title

Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition (English)

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19 March 2020

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Antonella Papa

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Robin M Hobbs

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Ming Chen

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John G Clohessy

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Pier Paolo Pandolfi

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Sabina Signoretti

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4

Min Sup Song

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Andrea Lunardi

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Mirjam T Epping

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Caterina Nardella

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2

Nina Seitzer

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John M Asara

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Massimo Loda

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Kaitlyn A Webster

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Akash Patnaik

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author name string

Enrique González-Billalabeitia

1

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19 March 2020

Su Jung Song

3

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Christopher Ng

12

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Lewis C Cantley

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publication date

27 May 2014

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19 March 2020

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volume

4

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issue

8

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19 March 2020

page(s)

896-904

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Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer

19 March 2020

cites work

1 reference

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The functions and regulation of the PTEN tumour suppressor

9 September 2017

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Akt signalling in health and disease.

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Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

9 September 2017

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Class 1A PI3K regulates vessel integrity during development and tumorigenesis

9 September 2017

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Clinical practice. Localized prostate cancer

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Expectant management of prostate cancer with curative intent: an update of the Johns Hopkins experience

9 September 2017

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In vivo MRI volumetric measurement of prostate regression and growth in mice

9 September 2017

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AKT/PKB signaling: navigating downstream

9 September 2017

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

9 September 2017

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

9 September 2017

1 reference

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

9 September 2017

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Pten dose dictates cancer progression in the prostate

9 September 2017

1 reference

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Prostatic intraepithelial neoplasia in genetically engineered mice

9 September 2017

1 reference

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

9 September 2017

1 reference

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Pten is essential for embryonic development and tumour suppression

9 September 2017

1 reference

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

9 September 2017

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

9 September 2017

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A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer

9 September 2017

1 reference

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Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress.

9 September 2017

1 reference

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Lack of PTEN sequesters CHK1 and initiates genetic instability.

14 September 2017

1 reference

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PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

14 September 2017

1 reference

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Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging

17 June 2018

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10.1158/2159-8290.CD-13-0230

21 August 2018

Identifiers

DOI

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19 March 2020

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19 March 2020

PubMed publication ID

24866151

1 reference