Obesity and Cancer Mechanisms: Cancer Metabolism. (Q39024765)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903152%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

review article

1 reference

title

Obesity and Cancer Mechanisms: Cancer Metabolism (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903152%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903152%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

author name string

Benjamin D Hopkins

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903152%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

Lewis C Cantley

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903152%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

language of work or name

English

0 references

publication date

7 November 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903152%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Oncology

28 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903152%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

volume

34

1 reference

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28 March 2020

issue

35

1 reference

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28 March 2020

page(s)

4277-4283

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903152%20AND%20SRC:MED&resulttype=core&format=json

Proteomic modulation in breast tumors after metformin exposure: results from a "window of opportunity" trial.

28 March 2020

cites work

1 reference

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1 October 2017

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Measuring the biological effect of presurgical metformin treatment in endometrial cancer.

1 October 2017

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1 October 2017

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Metformin: risk-benefit profile with a focus on cancer

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1 October 2017

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Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet

1 October 2017

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Mitochondrial free fatty acid β-oxidation supports oxidative phosphorylation and proliferation in cancer cells.

1 October 2017

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Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial

1 October 2017

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Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation.

1 October 2017

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Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study

1 October 2017

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Multidrug and toxin extrusion 1 and human organic cation transporter 1 polymorphisms in patients with castration-resistant prostate cancer receiving metformin (SAKK 08/09).

1 October 2017

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Effect of metformin vs placebo on and metabolic factors in NCIC CTG MA.32.

1 October 2017

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Highly specific role of the insulin receptor in breast cancer progression

1 October 2017

1 reference

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Evidence for biological effects of metformin in operable breast cancer: biomarker analysis in a pre-operative window of opportunity randomized trial

1 October 2017

1 reference

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Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer.

1 October 2017

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Antiproliferative and metabolic effects of metformin in a preoperative window clinical trial for endometrial cancer.

1 October 2017

1 reference

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Metformin and erlotinib synergize to inhibit basal breast cancer

1 October 2017

1 reference

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Metformin does not reduce markers of cell proliferation in esophageal tissues of patients with Barrett's esophagus.

1 October 2017

1 reference

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Metformin and gynecologic cancers

1 October 2017

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Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults

1 October 2017

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Lipid catabolism via CPT1 as a therapeutic target for prostate cancer

1 October 2017

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Anti-diabetic doses of metformin decrease proliferation markers in tumors of patients with endometrial cancer

1 October 2017

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Acyl-coenzyme A-binding protein regulates Beta-oxidation required for growth and survival of non-small cell lung cancer

1 October 2017

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ERGO: a pilot study of ketogenic diet in recurrent glioblastoma

1 October 2017

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1 October 2017

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Presurgical trial of metformin in overweight and obese patients with newly diagnosed breast cancer

1 October 2017

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Increased IR-A/IR-B ratio in non-small cell lung cancers associates with lower epithelial-mesenchymal transition signature and longer survival in squamous cell lung carcinoma

1 October 2017

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1 October 2017

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Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme

1 October 2017

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A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors

1 October 2017

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Impact of sarcopenia on the prognosis and treatment toxicities in patients diagnosed with cancer.

1 October 2017

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1 October 2017

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Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRAS(G12D)-driven lung tumors

1 October 2017

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Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets

1 October 2017

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Adipose tissue and adipocytes support tumorigenesis and metastasis

1 October 2017

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Dietary sugars and body weight: systematic review and meta-analyses of randomised controlled trials and cohort studies

1 October 2017

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Obesity, energy balance, and cancer: new opportunities for prevention

1 October 2017

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Effect of insulin analogues on insulin/IGF1 hybrid receptors: increased activation by glargine but not by its metabolites M1 and M2

1 October 2017

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Stromal estrogen receptor-α promotes tumor growth by normalizing an increased angiogenesis.

1 October 2017

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The insulin and insulin-like growth factor receptor family in neoplasia: an update

1 October 2017

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1 October 2017

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Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes

1 October 2017

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1 October 2017

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Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II.

1 October 2017

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Altered expression of insulin receptor isoforms in breast cancer

1 October 2017

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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

1 October 2017

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Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia

1 October 2017

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Androgen receptor signaling in prostate cancer development and progression

1 October 2017

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Does intentional weight loss reduce cancer risk?

1 October 2017

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Minireview: IGF, Insulin, and Cancer

1 October 2017

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The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

1 October 2017

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Energy balance modulates colon tumor growth: Interactive roles of insulin and estrogen

1 October 2017

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National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants

1 October 2017

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Metformin and other biguanides in oncology: advancing the research agenda

1 October 2017

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Energy balance, host-related factors, and cancer progression

1 October 2017

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Insulin signaling meets mitochondria in metabolism

1 October 2017

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1 October 2017

Androgens and obesity

1 reference

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Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

1 October 2017

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New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

1 October 2017

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

1 October 2017

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Minireview: Obesity and breast cancer: the estrogen connection

1 October 2017

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Tumours with PI3K activation are resistant to dietary restriction

1 October 2017

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Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women

1 October 2017

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Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival.

1 October 2017

1 reference

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Insulin and insulin-like growth factor signalling in neoplasia

1 October 2017

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Cancer cell metabolism: Warburg and beyond

1 October 2017

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Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity

1 October 2017

1 reference

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The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial

1 October 2017

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Effects of adiponectin on breast cancer cell growth and signaling

1 October 2017

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Non-islet cell tumour-induced hypoglycaemia: a review of the literature including two new cases

1 October 2017

1 reference

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Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Exercise for overweight or obesity

1 October 2017

1 reference

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Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line.

1 October 2017

1 reference

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Estrogen carcinogenesis in breast cancer

1 October 2017

1 reference

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Adiponectin as a growth inhibitor in prostate cancer cells

1 October 2017

1 reference

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Adipocytokines and cancer

1 October 2017

1 reference

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1 October 2017

1 reference

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Obesity and cortisol status

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

1 October 2017

1 reference

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Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review

1 October 2017

1 reference

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The role of the IGF system in cancer: from basic to clinical studies and clinical applications

1 October 2017

1 reference

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Mechanisms of energy restriction: effects of corticosterone on cell growth, cell cycle machinery, and apoptosis.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Cellular mechanisms of insulin resistance

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

1 October 2017

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Leptin and the regulation of body weight in mammals

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Insulin-like growth factor 1 and prostate cancer risk: a population-based, case-control study

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Role of genomic imprinting in Wilms' tumour and overgrowth disorders

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

The insulin signaling system

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Proceedings: Causes of death in cancer patients

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Elevated insulin receptor content in human breast cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Activation of phosphatidylinositol 3-kinase by insulin

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Hyperinsulinemia, insulin resistance and colorectal adenomas: A meta-analysis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Phase I study of intermittent oral dosing of the insulin-like growth factor-1 and insulin receptors inhibitor OSI-906 in patients with advanced solid tumors

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Circulating levels of insulin-like growth factor-II/mannose-6-phosphate receptor in obesity and type 2 diabetes

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Insulin receptor expression and clinical outcome in node-negative breast cancer

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

(Ir)relevance of Metformin Treatment in Patients with Metastatic Pancreatic Cancer: An Open-Label, Randomized Phase II Trial.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Effect of Metformin on Breast Ductal Carcinoma In Situ Proliferation in a Randomized Presurgical Trial.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Targeting insulin inhibition as a metabolic therapy in advanced cancer: a pilot safety and feasibility dietary trial in 10 patients

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Dual effect of metformin on breast cancer proliferation in a randomized presurgical trial.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Chemoprevention meets glucose control

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Interaction between adiponectin and leptin influences the risk of colorectal adenoma.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Expression of insulin-like growth factor 2 in mesenchymal neoplasms

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Quantitative mass spectrometry identifies insulin signaling targets in C. elegans

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Hyperinsulinaemia: a prospective risk factor for lethal clinical prostate cancer

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Serum Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein-3 Concentrations and Prostate Cancer Risk: Results from the European Prospective Investigation into Cancer and Nutrition

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

IGF-I, IGF binding protein-3 and breast cancer risk: Comparison of 3 meta-analyses

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562429

Loss of IGF2 imprinting: a potential marker of colorectal cancer risk

1 October 2018

1 reference

12 December 2020

Prostate cancer cell-adipocyte interaction: leptin mediates androgen-independent prostate cancer cell proliferation through c-Jun NH2-terminal kinase

1 reference

12 December 2020

The effects of the ketogenic diet in refractory partial seizures with reference to tuberous sclerosis

1 reference

12 December 2020

A high-fat, ketogenic diet induces a unique metabolic state in mice

1 reference

12 December 2020

The role of protein in weight loss and maintenance

1 reference

12 December 2020

Phase 2 Trial of Metformin Combined With 5-Fluorouracil in Patients With Refractory Metastatic Colorectal Cancer

1 reference

12 December 2020

Identifiers

DOI

10.1200/JCO.2016.67.9712

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903152%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27903152%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

PubMed publication ID

27903152

1 reference