Leucine and Mammalian Target of Rapamycin-Dependent Activation of Muscle Protein Synthesis in Aging (Q39033981)

8 September 2017

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title

Leucine and Mammalian Target of Rapamycin-Dependent Activation of Muscle Protein Synthesis in Aging (English)

1 reference

8 September 2017

Jean-Pascal De Bandt

1

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PubMed ID

27934653

8 September 2017

language of work or name

English

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publication date

9 November 2016

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8 September 2017

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8 September 2017

146

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8 September 2017

2616S-2624S

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8 September 2017

12

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Sarcopenic obesity in the elderly and strategies for weight management

8 September 2017

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

The developmental origins of sarcopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Human skeletal muscle aging and the oxidative system: cellular events

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Sarcopenia exacerbates obesity-associated insulin resistance and dysglycemia: findings from the National Health and Nutrition Examination Survey III.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Muscle function and fat content in relation to sarcopenia, obesity and frailty of old age--An overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Leucine. A possible regulator of protein turnover in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

The anabolic response to a meal containing different amounts of protein is not limited by the maximal stimulation of protein synthesis in healthy young adults

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Muscle protein synthesis in response to nutrition and exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Insulin receptor signaling in normal and insulin-resistant states

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Insulin action and insulin resistance in vascular endothelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

The physiological regulation of glucose flux into muscle in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Inability to stimulate skeletal muscle or whole body protein synthesis in type 1 (insulin-dependent) diabetic patients by insulin-plus-glucose during amino acid infusion: studies of incorporation and turnover of tracer L-[1-13C]leucine

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Effects of insulin and amino acids on leg protein turnover in IDDM patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Regulation of muscle protein synthesis and the effects of catabolic states

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

mTOR and autophagy: a dynamic relationship governed by nutrients and energy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Leucine and mTORC1: a complex relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

The tuberous sclerosis complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Bidirectional transport of amino acids regulates mTOR and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Amino acid regulation of TOR complex 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

A lysosome-centered view of nutrient homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Sestrin2 is a leucine sensor for the mTORC1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Regulation of Toll-like receptor-mediated Sestrin2 induction by AP-1, Nrf2, and the ubiquitin-proteasome system in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Metabolism. Differential regulation of mTORC1 by leucine and glutamine

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Regulation of muscle protein synthesis in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Nutritionally essential amino acids and metabolic signaling in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Protein Considerations for Optimising Skeletal Muscle Mass in Healthy Young and Older Adults

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

The rate of protein digestion affects protein gain differently during aging in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Insulin resistance and beta-cell dysfunction in aging: the importance of dietary carbohydrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Fast-digestive protein supplement for ten days overcomes muscle anabolic resistance in healthy elderly men.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Muscle protein anabolism in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Frailty status and altered glucose-insulin dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Postprandial Protein Handling Is Not Impaired in Type 2 Diabetes Patients When Compared With Normoglycemic Controls.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Effect of obesity and type 2 diabetes on protein anabolic response to insulin in elderly women.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Insulin resistance of protein metabolism in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Indications and contraindications for infusing specific amino acids (leucine, glutamine, arginine, citrulline, and taurine) in critical illness

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Postprandial muscle protein synthesis is higher after a high whey protein, leucine-enriched supplement than after a dairy-like product in healthy older people: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

High dietary protein intake, reducing or eliciting insulin resistance?

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Amino acid-induced impairment of insulin sensitivity in healthy and obese rats is reversible

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

The role of mTOR in lipid homeostasis and diabetes progression

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Interventions to Slow Aging in Humans: Are We Ready?

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

The conserved role of protein restriction in aging and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Branched-chain amino acids ameliorate fibrosis and suppress tumor growth in a rat model of hepatocellular carcinoma with liver cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Branched chain amino acid suppresses hepatocellular cancer stem cells through the activation of mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Branched-chain amino acids enhance premature senescence through mammalian target of rapamycin complex I-mediated upregulation of p21 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

Effect of branched-chain amino acids on muscle atrophy in cancer cachexia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

The effect of leucine restriction on Akt/mTOR signaling in breast cancer cell lines in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.116.234518

21 January 2018

Identifiers

DOI

10.3945/JN.116.234518

1 reference

release_rxv54loa3zhu5luyx33xnubfym

8 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/rxv54loa3zhu5luyx33xnubfym

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

27934653

1 reference

PubMed ID

27934653