Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates (Q39076892)

8 September 2017

Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates (English)

1 reference

8 September 2017

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25503696%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

M A Kotterman

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25503696%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

L Yin

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25503696%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

J M Strazzeri

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25503696%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

W H Merigan

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25503696%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

D V Schaffer

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25503696%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

publication date

11 December 2014

1 reference

8 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25503696%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25503696%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

116-126

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25503696%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25503696%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/gt.2014.115

11 June 2020

exact match

0 references

cites work

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9 September 2017

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9 September 2017

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The assembly-activating protein promotes capsid assembly of different adeno-associated virus serotypes

9 September 2017

1 reference

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Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years

9 September 2017

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Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure

9 September 2017

1 reference

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9 September 2017

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Impact of pre-existing immunity on gene transfer to nonhuman primate liver with adeno-associated virus 8 vectors

9 September 2017

1 reference

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Intravitreal injection of AAV2 transduces macaque inner retina

9 September 2017

1 reference

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A viral assembly factor promotes AAV2 capsid formation in the nucleolus

9 September 2017

1 reference

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Review of the clinical development of alipogene tiparvovec gene therapy for lipoprotein lipase deficiency

9 September 2017

1 reference

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Safety and efficacy of subretinal readministration of a viral vector in large animals to treat congenital blindness

9 September 2017

1 reference

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The pleiotropic effects of natural AAV infections on liver-directed gene transfer in macaques

9 September 2017

1 reference

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Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial

9 September 2017

1 reference

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A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells

9 September 2017

1 reference

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Molecular evolution of adeno-associated virus for enhanced glial gene delivery

9 September 2017

1 reference

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Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 year

9 September 2017

1 reference

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Intravitreal delivery of AAV8 retinoschisin results in cell type-specific gene expression and retinal rescue in the Rs1-KO mouse

9 September 2017

1 reference

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Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial.

9 September 2017

1 reference

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Directed evolution of adeno-associated virus to an infectious respiratory virus

9 September 2017

1 reference

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Defining the residual vision in leber congenital amaurosis caused by RPE65 mutations

9 September 2017

1 reference

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High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors

9 September 2017

1 reference

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Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential

9 September 2017

1 reference

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Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial

9 September 2017

1 reference

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DNA shuffling of adeno-associated virus yields functionally diverse viral progeny

9 September 2017

1 reference

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9 September 2017

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Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses

9 September 2017

1 reference

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Effect of gene therapy on visual function in Leber's congenital amaurosis

9 September 2017

1 reference

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Safety and efficacy of gene transfer for Leber's congenital amaurosis

9 September 2017

1 reference

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In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses

9 September 2017

1 reference

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Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations

9 September 2017

1 reference

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Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin.

9 September 2017

1 reference

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Characterization of cytokine responses to retinal detachment in rats.

9 September 2017

1 reference

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Adeno-associated virus serotypes: vector toolkit for human gene therapy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

9 September 2017

1 reference

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Directed evolution of adeno-associated virus yields enhanced gene delivery vectors

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Clades of Adeno-associated viruses are widely disseminated in human tissues.

9 September 2017

1 reference

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Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Gene therapy progress and prospects: recombinant adeno-associated virus (rAAV) vectors

9 September 2017

1 reference

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Gene delivery to the eye using adeno-associated viral vectors

9 September 2017

1 reference

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Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

9 September 2017

1 reference

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Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection

9 September 2017

1 reference

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Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes

9 September 2017

1 reference

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Human adeno-associated virus type 5 is only distantly related to other known primate helper-dependent parvoviruses

9 September 2017

1 reference

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Successful readministration of adeno-associated virus vectors to the mouse lung requires transient immunosuppression during the initial exposure

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration.

9 September 2017

1 reference

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Complications of vitrectomy for non-clearing vitreous hemorrhage in diabetic patients

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

AAV-mediated gene delivery in Dp71-null mouse model with compromised barriers

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Epitope mapping of human anti-adeno-associated virus type 2 neutralizing antibodies: implications for gene therapy and virus structure

9 September 2017

1 reference

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Gene therapy vectors based on adeno-associated virus type 1.

14 September 2017

1 reference

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Immune response against gene therapy vectors: influence of synovial fluid on adeno-associated virus mediated gene transfer to chondrocytes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Striatal delivery of rAAV-hAADC to rats with preexisting immunity to AAV.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Overcoming preexisting humoral immunity to AAV using capsid decoys

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Changes in adeno-associated virus-mediated gene delivery in retinal degeneration

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Impact of preexisting vector immunity on the efficacy of adeno-associated virus-based HIV-1 Gag vaccines.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Intraocular injection of tamoxifen-loaded nanoparticles: a new treatment of experimental autoimmune uveoretinitis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: implications for gene therapy using AAV vectors

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Intramuscular administration of AAV1-lipoprotein lipase S447X lowers triglycerides in lipoprotein lipase-deficient patients

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Synoviocyte infection with adeno-associated virus (AAV) is neutralized by human synovial fluid from arthritis patients and depends on AAV serotype

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Immune responses to AAV in a phase I study for Canavan disease.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Mutations on the external surfaces of adeno-associated virus type 2 capsids that affect transduction and neutralization

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Combinatorial engineering of a gene therapy vector: directed evolution of adeno-associated virus

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Genetic modifications of the adeno-associated virus type 2 capsid reduce the affinity and the neutralizing effects of human serum antibodies

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Transient immunosuppression allows transgene expression following readministration of adeno-associated viral vectors

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Cell-mediated immune response and stability of intraocular transgene expression after adenovirus-mediated delivery

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4393652

Intraocular antibody synthesis during experimental uveitis

4 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25503696

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effect of alipogene tiparvovec (AAV1-LPL(S447X)) on postprandial chylomicron metabolism in lipoprotein lipase-deficient patients

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25503696

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/GT.2014.115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25503696%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25503696%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference