5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors (Q39080441)

8 September 2017

5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors (English)

1 reference

8 September 2017

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24120088%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Michael J Dapp

6

1 reference

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1 June 2020

author name string

Jonathan M Rawson

1

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1 June 2020

Richard H Heineman

2

1 reference

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1 June 2020

Jessica L Martin

4

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1 June 2020

Erica K Schnettler

5

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1 June 2020

Steven E Patterson

7

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1 June 2020

Louis M Mansky

8

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1 June 2020

language of work or name

English

0 references

publication date

20 August 2013

1 reference

Bioorganic & Medicinal Chemistry

8 September 2017

1 reference

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1 June 2020

volume

21

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1 June 2020

page(s)

7222-7228

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1 June 2020

issue

22

1 reference

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Safety, tolerability, and efficacy of KP-1461 as monotherapy for 124 days in antiretroviral-experienced, HIV type 1-infected subjects

1 June 2020

cites work

1 reference

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Resveratrol and health--a comprehensive review of human clinical trials

9 September 2017

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Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461

9 September 2017

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Clinical trials of resveratrol

9 September 2017

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Exploiting drug repositioning for discovery of a novel HIV combination therapy

9 September 2017

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Potential benefits of sequential inhibitor-mutagen treatments of RNA virus infections

9 September 2017

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5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1.

9 September 2017

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Chemical decomposition of 5-aza-2'-deoxycytidine (Decitabine): kinetic analyses and identification of products by NMR, HPLC, and mass spectrometry.

9 September 2017

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Lethal mutagenesis of HIV.

9 September 2017

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Viral error catastrophe by mutagenic nucleosides

9 September 2017

1 reference

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Unselected mutations in the human immunodeficiency virus type 1 genome are mostly nonsynonymous and often deleterious

9 September 2017

1 reference

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RNA virus error catastrophe: direct molecular test by using ribavirin

9 September 2017

1 reference

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Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity

9 September 2017

1 reference

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Inhibition of human immunodeficiency virus type 1 replication in human mononuclear blood cells by the iron chelators deferoxamine, deferiprone, and bleomycin

9 September 2017

1 reference

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Lethal mutagenesis of HIV with mutagenic nucleoside analogs

9 September 2017

1 reference

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Deoxyribonucleoside triphosphate pool imbalances in vivo are associated with an increased retroviral mutation rate

9 September 2017

1 reference

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Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase

9 September 2017

1 reference

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Negative effects of chemical mutagenesis on the adaptive behavior of vesicular stomatitis virus

9 September 2017

1 reference

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Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replication

9 September 2017

1 reference

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A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

9 September 2017

1 reference

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Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase

9 September 2017

1 reference

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Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine

9 September 2017

1 reference

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A phase I clinical, plasma, and cellular pharmacology study of gemcitabine

9 September 2017

1 reference

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Isolation, characterization, and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine

9 September 2017

1 reference

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Back to the future: revisiting HIV-1 lethal mutagenesis

9 September 2017

1 reference

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5-Azacytidine Hydrolysis Kinetics Measured by High-Pressure Liquid Chromatography and 13C-NMR Spectroscopy

9 September 2017

1 reference

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Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides

14 September 2017

1 reference

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Combination of a mutagenic agent with a reverse transcriptase inhibitor results in systematic inhibition of HIV-1 infection

14 September 2017

1 reference

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KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis

14 September 2017

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Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV).

14 September 2017

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Mutation Frequencies at Defined Single Codon Sites in Vesicular Stomatitis Virus and Poliovirus Can Be Increased Only Slightly by Chemical Mutagenesis

14 September 2017

1 reference

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Mutational analysis of HIV-1 long terminal repeats to explore the relative contribution of reverse transcriptase and RNA polymerase II to viral mutagenesis

14 September 2017

1 reference

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Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses

25 September 2017

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Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate: a mechanism of self-potentiation

25 September 2017

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Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine

15 June 2018

1 reference

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Characterization of decomposition products and preclinical and low dose clinical pharmacokinetics of decitabine (5-aza-2'-deoxycytidine) by a new liquid chromatography/tandem mass spectrometry quantification method

21 August 2018

1 reference

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Mechanism of action of a novel viral mutagenic covert nucleotide: molecular interactions with HIV-1 reverse transcriptase and host cell DNA polymerases

21 August 2018

1 reference

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Synergistic inhibition of HIV-1 in activated and resting peripheral blood mononuclear cells, monocyte-derived macrophages, and selected drug-resistant isolates with nucleoside analogues combined with a natural product, resveratrol

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3930610

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3930610

Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines.

21 August 2018

1 reference

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Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication

21 August 2018

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Anti-human immunodeficiency virus type 1 activity of hydroxyurea in combination with 2',3'-dideoxynucleosides

21 August 2018

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Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis

21 August 2018

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12 December 2020

Safety, Tolerability, and Pharmacokinetics of KP-1461 in Phase I Clinical Studies: A Single Oral Dose Study in Non-HIV-Infected Adults, and a 14-Day Dose-Escalating Study in Highly Antiretroviral-Experienced HIV-Infected Adults

1 reference

12 December 2020

Resveratrol, a remarkable inhibitor of ribonucleotide reductase

1 reference

12 December 2020

Action of 2',2'-difluorodeoxycytidine on DNA synthesis

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12 December 2020

Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine

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12 December 2020

2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase

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12 December 2020

High-performance Liquid Chromatographic Analysis of Chemical Stability of 5-aza-2′-Deoxycytidine

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12 December 2020

Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators

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12 December 2020

10.1016/J.BMC.2013.08.023

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24120088%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

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1 June 2020

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