Excessive MET signaling causes acquired resistance and addiction to MET inhibitors in the MKN45 gastric cancer cell line (Q39169189)

9 September 2017

title

Excessive MET signaling causes acquired resistance and addiction to MET inhibitors in the MKN45 gastric cancer cell line (English)

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9 September 2017

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9

Naomi Kiyota

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9 September 2017

Yohei Funakoshi

1

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9 September 2017

Toru Mukohara

2

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9 September 2017

Hideo Tomioka

3

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9 September 2017

Roudy Chiminch Ekyalongo

4

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9 September 2017

Yu Kataoka

5

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9 September 2017

Yumiko Inui

6

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9 September 2017

Yuriko Kawamori

7

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9 September 2017

Masanori Toyoda

8

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9 September 2017

Yutaka Fujiwara

10

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9 September 2017

Hironobu Minami

11

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9 September 2017

publication date

9 April 2013

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Investigational New Drugs

9 September 2017

published in

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9 September 2017

volume

31

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9 September 2017

issue

5

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9 September 2017

page(s)

1158-1168

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Activation of tyrosine kinases in cancer

9 September 2017

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MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

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Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency

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MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors

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Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors

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Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

21 January 2018

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Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer

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Conversion from the "oncogene addiction" to "drug addiction" by intensive inhibition of the EGFR and MET in lung cancer with activating EGFR mutation

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Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study

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21 January 2018

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

21 January 2018

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ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress

21 January 2018

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Overexpression of BLCAP induces S phase arrest and apoptosis independent of p53 and NF-kappaB in human tongue carcinoma : BLCAP overexpression induces S phase arrest and apoptosis

21 January 2018

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21 January 2018

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21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23568717

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S10637-013-9959-2

1 reference

9 September 2017

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