The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosis (Q39170414)

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scientific article published on 2 April 2013

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English	The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosis	scientific article published on 2 April 2013

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scholarly article

1 reference

Europe PubMed Central

9 September 2017

The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosis (English)

1 reference

Europe PubMed Central

9 September 2017

apoptotic process

1 reference

based on heuristic

inferred from title

8

object named as

Fadlo R Khuri

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Europe PubMed Central

9 September 2017

author name string

Hui Ren

1

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Europe PubMed Central

9 September 2017

Liqun Zhao

2

1 reference

Europe PubMed Central

9 September 2017

Yikun Li

3

1 reference

Europe PubMed Central

9 September 2017

Ping Yue

4

1 reference

Europe PubMed Central

9 September 2017

Xingming Deng

5

1 reference

Europe PubMed Central

9 September 2017

Taofeek K Owonikoko

6

1 reference

Europe PubMed Central

9 September 2017

Mingwei Chen

7

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Europe PubMed Central

9 September 2017

Shi-Yong Sun

9

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Europe PubMed Central

9 September 2017

language of work or name

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publication date

2 April 2013

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Europe PubMed Central

9 September 2017

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Europe PubMed Central

9 September 2017

338

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Europe PubMed Central

9 September 2017

2

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Europe PubMed Central

9 September 2017

229-238

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Europe PubMed Central

9 September 2017

Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3750077

10 September 2017

Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3750077

10 September 2017

Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3750077

10 September 2017

Antitumor activity of NVP-BKM120--a selective pan class I PI3 kinase inhibitor showed differential forms of cell death based on p53 status of glioma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3750077

10 September 2017

Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells

1 reference

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10 September 2017

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

1 reference

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10 September 2017

TRAIL receptor signaling and therapeutics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3750077

10 September 2017

Mcl-1; the molecular regulation of protein function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3750077

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PI3K-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytes

1 reference

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TRAIL agonists on clinical trials for cancer therapy: the promises and the challenges

1 reference

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BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells

1 reference

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Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation

1 reference

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To kill a tumor cell: the potential of proapoptotic receptor agonists

1 reference

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10 September 2017

Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells

1 reference

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10 September 2017

BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells

1 reference

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Modulation of death receptors by cancer therapeutic agents

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Chemopreventive agent-induced modulation of death receptors

1 reference

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Mechanisms of resistance to TRAIL-induced apoptosis in cancer

1 reference

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Targeting death receptors in cancer with Apo2L/TRAIL.

1 reference

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The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

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Proteins of the bcl-2 family in apoptosis signalling: from mechanistic insights to therapeutic opportunities.

1 reference

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Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease

1 reference

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The biochemistry of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3750077

10 September 2017

Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3750077

10 September 2017

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

1 reference

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14 September 2017

A dual PI3K/mTOR inhibitor, PI-103, cooperates with stem cell-delivered TRAIL in experimental glioma models

1 reference

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14 September 2017

TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1.

1 reference

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BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis

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Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death.

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Sensitization of prostate carcinoma cells to Apo2L/TRAIL by a Bcl-2 family protein inhibitor

1 reference

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1 reference

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https://pubmed.ncbi.nlm.nih.gov/23562472

12 December 2020

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1 reference

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inferred from PubMed ID database lookup

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10.1016/J.CANLET.2013.03.032

1 reference

Europe PubMed Central

9 September 2017

1 reference

Europe PubMed Central

9 September 2017

1 reference

Europe PubMed Central

9 September 2017

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