CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes (Q39185214)

9 September 2017

CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes (English)

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9 September 2017

Kiyoshi Migita

1

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9 September 2017

Atsumasa Komori

2

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9 September 2017

Takafumi Torigoshi

3

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9 September 2017

Yumi Maeda

4

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9 September 2017

Yasumori Izumi

5

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9 September 2017

Yuka Jiuchi

6

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9 September 2017

Taiichiro Miyashita

7

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9 September 2017

Minoru Nakamura

8

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9 September 2017

Satoru Motokawa

9

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9 September 2017

Hiromi Ishibashi

10

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9 September 2017

6 May 2011

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Arthritis Research and Therapy

9 September 2017

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9 September 2017

13

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9 September 2017

3

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9 September 2017

R72

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https://scigraph.springernature.com/pub.10.1186/ar3333

9 September 2017

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Promising bone-related therapeutic targets for rheumatoid arthritis

10 September 2017

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The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo

10 September 2017

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CP-690550, a JAK3 inhibitor as an immunosuppressant for the treatment of rheumatoid arthritis, transplant rejection, psoriasis and other immune-mediated disorders

10 September 2017

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Interleukin-6 as a key player in systemic inflammation and joint destruction.

10 September 2017

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Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)

10 September 2017

1 reference

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The JAK kinases: not just another kinase drug discovery target

10 September 2017

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MAPKs and their relevance to arthritis and inflammation

10 September 2017

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Interleukin 6: from bench to bedside

10 September 2017

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Changes in synovial tissue Jak-STAT expression in rheumatoid arthritis in response to successful DMARD treatment

10 September 2017

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Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs.

10 September 2017

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JAK3 inhibition, a viable new modality of immunosuppression for solid organ transplants

10 September 2017

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Rheumatoid arthritis: regulation of synovial inflammation

10 September 2017

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Principles of interleukin (IL)-6-type cytokine signalling and its regulation

10 September 2017

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Signaling through the JAK/STAT pathway, recent advances and future challenges

10 September 2017

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Of genes and phenotypes: the immunological and molecular spectrum of combined immune deficiency. Defects of the gamma(c)-JAK3 signaling pathway as a model

10 September 2017

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Janus kinases: components of multiple signaling pathways

10 September 2017

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Signalling by cytokines interacting with the interleukin-2 receptor gamma chain.

10 September 2017

1 reference

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Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

10 September 2017

1 reference

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Detection of oncostatin M in synovial fluid from patients with rheumatoid arthritis

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218881

Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7

10 September 2017

1 reference

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The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

10 September 2017

1 reference

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Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218881

The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

21 August 2018

1 reference

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Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

21 August 2018

1 reference

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Murine oncostatin M stimulates mouse synovial fibroblasts in vitro and induces inflammation and destruction in mouse joints in vivo.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218881

Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures

21 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FAR3333

The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha- or IL-1beta-stimulated rheumatoid synovial fibroblasts

21 January 2018

1 reference

12 December 2020

Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice

1 reference

12 December 2020

1 reference

12 December 2020

Oncostatin M stimulates monocyte chemoattractant protein-1- and interleukin-1-induced matrix metalloproteinase-1 production by human synovial fibroblasts in vitro

1 reference

12 December 2020

Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis

1 reference

12 December 2020

Identifiers

DOI

10.1186/AR3333

1 reference

Dimensions Publication ID

9 September 2017

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1 reference

9 September 2017

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