SIRT1 silencing confers neuroprotection through IGF-1 pathway activation (Q39202722)

9 September 2017

SIRT1 silencing confers neuroprotection through IGF-1 pathway activation (English)

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9 September 2017

Luigi Sansone

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Lidia Villanova

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Lidia Villanova

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Marcella Nebbioso

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Marcella Nebbioso

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Valentina Reali

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9 September 2017

Laura Pellegrini

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9 September 2017

Michele Aventaggiato

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Gabriella Marfe

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Roberta Rosa

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Marco Tafani

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9 September 2017

Massimo Fini

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Matteo A Russo

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Bruna Pucci

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1 August 2013

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Journal of Cellular Physiology

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228

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8

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1754-1761

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Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

9 September 2017

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Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

21 January 2018

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Insulin/IGF-like signalling, the central nervous system and aging

21 January 2018

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The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration

21 January 2018

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The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated "anti-apoptotic" pathways

21 January 2018

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The role of the insulin-like growth factors in the central nervous system

21 January 2018

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Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state

21 January 2018

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A novel pathway regulates memory and plasticity via SIRT1 and miR-134

21 January 2018

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Insulin-like growth factor-1 improves somatosensory function and reduces the extent of cortical infarction and ongoing neuronal loss after hypoxia-ischemia in rats.

21 January 2018

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Insulin-like growth factor-1 and post-ischemic brain injury

21 January 2018

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Franklin H. Epstein Lecture: Sirtuins, aging, and medicine

21 January 2018

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Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons

21 January 2018

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Insulin-like growth factor-1-mediated neuroprotection against oxidative stress is associated with activation of nuclear factor kappaB.

21 January 2018

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Nicotinamide treatment provides acute neuroprotection and GFAP regulation following fluid percussion injury

21 January 2018

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Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection.

21 January 2018

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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

21 January 2018

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Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

21 January 2018

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The IGF-I signaling pathway

21 January 2018

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SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

21 January 2018

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Preventing NAD(+) depletion protects neurons against excitotoxicity: bioenergetic effects of mild mitochondrial uncoupling and caloric restriction

21 January 2018

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Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons

21 January 2018

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Linking sirtuins, IGF-I signaling, and starvation

21 January 2018

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Insulin-like growth factor-1 ameliorates age-related behavioral deficits.

21 January 2018

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Mammalian SIRT1 represses forkhead transcription factors

21 January 2018

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SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

21 January 2018

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Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity

21 January 2018

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

21 January 2018

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Insulin-like growth factor-1 inhibits STS-induced cell death and increases functional recovery of in vitro differentiated neurons.

21 January 2018

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Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

21 January 2018

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Sirt1 increases skeletal muscle precursor cell proliferation

21 January 2018

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Brain IRS2 signaling coordinates life span and nutrient homeostasis

21 January 2018

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Resveratrol is neuroprotective because it is not a direct activator of Sirt1-A hypothesis

21 January 2018

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Role of insulin-like growth factor I signaling in neurodegenerative diseases.

21 January 2018

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Insulin signaling in the central nervous system: learning to survive

21 January 2018

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

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Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCP.24334

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9 September 2017

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