Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. (Q35935771)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22509023%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation (English)

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29 January 2020

1

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29 January 2020

Patrick S. Ward

4

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29 January 2020

Jing Fan

5

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7

Craig B Thompson

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29 January 2020

author name string

Anthony Mancuso

2

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29 January 2020

Xuemei Tong

3

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Joshua D Rabinowitz

6

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language of work or name

English

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publication date

16 April 2012

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Proceedings of the National Academy of Sciences of the United States of America

29 January 2020

published in

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volume

109

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issue

18

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29 January 2020

page(s)

6904-6909

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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

29 January 2020

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

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Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

2 October 2017

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2 October 2017

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2 October 2017

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Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis

2 October 2017

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2 October 2017

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2 October 2017

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The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

2 October 2017

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Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

2 October 2017

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

2 October 2017

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Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

2 October 2017

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Atf4 regulates obesity, glucose homeostasis, and energy expenditure

2 October 2017

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Bidirectional transport of amino acids regulates mTOR and autophagy

2 October 2017

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Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

2 October 2017

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

2 October 2017

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

2 October 2017

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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

2 October 2017

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2 October 2017

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2 October 2017

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

2 October 2017

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Immunohistological demonstration of the same type of pyruvate kinase isoenzyme (M2-Pk) in tumors of chicken and rat

2 October 2017

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Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma

21 January 2018

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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11 July 2018

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11 July 2018

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11 July 2018

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24 September 2018

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Differentiation in vivo and in vitro of pyruvate kinase isozymes in rat muscle

24 September 2018

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12 December 2020

Genetic and epigenetic control of the pyruvate kinase isozymes in mammals

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12 December 2020

Pattern of pyruvate kinase isozymes in erythroleukemia cell lines and in normal human erythroblasts

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12 December 2020

Comparative kinetic behaviour and regulation by fructose-1,6-bisphosphate and ATP of pyruvate kinase from erythrocytes, reticulocytes and bone marrow cells

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12 December 2020

Quantification of tumor type M2 pyruvate kinase (Tu M2-PK) in human carcinomas

1 reference

12 December 2020

Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids

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12 December 2020

Kinetic evidence for the presence of two forms of M2-type pyruvate kinase in rat small intestine

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12 December 2020

Pyruvate kinase isozymes in man. II. L type and erythrocyte-type isozymes. Electrofocusing and immunologic studies

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12 December 2020

Pyruvate kinase isozymes in various tissues of rat, and increase of spleen-type pyruvate kinase in liver by injecting chromatins from spleen and tumor

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1204176109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22509023%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

0 references

1 reference

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29 January 2020

PubMed publication ID

22509023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22509023%20AND%20SRC:MED&resulttype=core&format=json