Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts (Q39233221)

10 September 2017

Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts (English)

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cancer-associated fibroblast

10 September 2017

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L J A C Hawinkels

1

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10 September 2017

M Paauwe

2

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10 September 2017

H W Verspaget

3

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10 September 2017

E Wiercinska

4

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10 September 2017

J M van der Zon

5

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10 September 2017

K van der Ploeg

6

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10 September 2017

P J Koelink

7

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J H N Lindeman

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10 September 2017

W Mesker

9

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10 September 2017

P ten Dijke

10

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C F M Sier

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10 September 2017

language of work or name

English

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publication date

3 December 2012

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10 September 2017

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10 September 2017

33

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1

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10 September 2017

97-107

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https://scigraph.springernature.com/pub.10.1038/onc.2012.536

10 September 2017

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Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?

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Immunomodulatory effects of tumor-associated fibroblasts in colorectal-tumor development

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Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

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Role of transforming growth factor beta in human disease

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TGF-beta signaling in tumor suppression and cancer progression

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Extracellular control of TGFbeta signalling in vascular development and disease

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Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors

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Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin

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The role of proteases in transforming growth factor-beta activation

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Making sense of latent TGFbeta activation

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The dynamic roles of TGF-β in cancer

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Age-dependent variations of human and rat colon myofibroblasts in culture: Influence on their functional interactions with colon cancer cells

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Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling.

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Induction of hepatocyte growth factor/scatter factor by fibroblast clustering directly promotes tumor cell invasiveness

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Fibroblast nemosis arrests growth and induces differentiation of human leukemia cells

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Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation

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Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression

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The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells

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Tumour-derived TGF-beta1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells

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Transforming growth factor-beta signaling in cancer invasion and metastasis

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Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer

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Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation.

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SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway

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Tissue level, activation and cellular localisation of TGF-beta1 and association with survival in gastric cancer patients

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Transforming growth factor-beta and breast cancer: Mammary gland development

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Active TGF-beta1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence

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Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1

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A heterologous 3-D coculture model of breast tumor cells and fibroblasts to study tumor-associated fibroblast differentiation.

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BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein

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Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship

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Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders

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Transforming growth factor-beta activation in irradiated murine mammary gland

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Exploring anti-TGF-β therapies in cancer and fibrosis.

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VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.536

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.536

Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.536

Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis.

31 March 2020

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The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.536

Cathepsin K is the principal protease in giant cell tumor of bone.

31 March 2020

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Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma

31 March 2020

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Cloning, cellular localization, genomic organization, and tissue-specific expression of the TGFbeta1-inducible SMAP-5 gene

31 March 2020

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Efficient degradation-aided selection of protease inhibitors by phage display.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2012.536

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Dimensions Publication ID

10 September 2017

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