Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization (Q39246559)

10 September 2017

Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization (English)

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10 September 2017

Stella Tommasi

1

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10 September 2017

Albert Zheng

2

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10 September 2017

Annette Weninger

3

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10 September 2017

Steven E Bates

4

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10 September 2017

Xuejun Arthur Li

5

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10 September 2017

Xiwei Wu

6

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10 September 2017

Monica Hollstein

7

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10 September 2017

Ahmad Besaratinia

8

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10 September 2017

language of work or name

English

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publication date

11 November 2012

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10 September 2017

Nucleic Acids Research

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10 September 2017

41

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10 September 2017

1

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10 September 2017

182-195

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Creative Commons Attribution-NonCommercial 3.0 Unported

10 September 2017

start time

4 October 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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The p53 network: cellular and systemic DNA damage responses in aging and cancer

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Non-coding RNAs in human disease

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Senescence and pre-malignancy: how do tumors progress?

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CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

10 September 2017

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Epigenetic alterations associated with cellular senescence: a barrier against tumorigenesis or a red carpet for cancer?

10 September 2017

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A decade of exploring the cancer epigenome - biological and translational implications

10 September 2017

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CpG islands and the regulation of transcription

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Cancer epigenetics reaches mainstream oncology

10 September 2017

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p38(MAPK) in the senescence of human and murine fibroblasts.

10 September 2017

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The role of signaling pathways in the development and treatment of hepatocellular carcinoma

10 September 2017

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Mechanisms and functions of p38 MAPK signalling.

10 September 2017

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Conserved role of intragenic DNA methylation in regulating alternative promoters

10 September 2017

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Investigating the epigenetic effects of a prototype smoke-derived carcinogen in human cells

10 September 2017

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Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo

10 September 2017

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Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding.

10 September 2017

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How to become immortal: let MEFs count the ways

10 September 2017

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Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing.

10 September 2017

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A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen

10 September 2017

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Principles and challenges of genomewide DNA methylation analysis

10 September 2017

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The senescence-associated secretory phenotype: the dark side of tumor suppression

10 September 2017

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Senescence in tumours: evidence from mice and humans

10 September 2017

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Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer

10 September 2017

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

10 September 2017

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Cellular senescence: molecular mechanisms, in vivo significance, and redox considerations

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains

10 September 2017

1 reference

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Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

10 September 2017

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Musashi1: a stem cell marker no longer in search of a function

10 September 2017

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Critical pathways in cellular senescence and immortalization revealed by gene expression profiling.

10 September 2017

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Living on a break: cellular senescence as a DNA-damage response

10 September 2017

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Analyzing real-time PCR data by the comparative C(T) method

10 September 2017

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DNA methylation landscapes: provocative insights from epigenomics

10 September 2017

1 reference

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Epigenetic gene regulation in cancer

10 September 2017

1 reference

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A novel CpG island set identifies tissue-specific methylation at developmental gene loci

10 September 2017

1 reference

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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

10 September 2017

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Hyperactive Ras in developmental disorders and cancer

10 September 2017

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Cancer epigenomics: DNA methylomes and histone-modification maps

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

The epigenomics of cancer

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Malignant melanoma: genetics and therapeutics in the genomic era.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Genomic models of metastatic cancer: functional analysis of death-from-cancer signature genes reveals aneuploid, anoikis-resistant, metastasis-enabling phenotype with altered cell cycle control and activated Polycomb Group (PcG) protein chromatin si

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Control of developmental regulators by Polycomb in human embryonic stem cells

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Polycomb complexes repress developmental regulators in murine embryonic stem cells

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Cancer in rodents: does it tell us about cancer in humans?

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

The profile of repeat-associated histone lysine methylation states in the mouse epigenome

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Understanding transformation: progress and gaps

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Mechanisms of cellular senescence in human and mouse cells.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

The ARF-p53 senescence pathway in mouse and human cells

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Mouse models with modified p53 sequences to study cancer and ageing.

10 September 2017

1 reference

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Initial sequencing and comparative analysis of the mouse genome

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Modelling the molecular circuitry of cancer

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

A novel active L1 retrotransposon subfamily in the mouse

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Genes involved in senescence and immortalization

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Senescence of human fibroblasts induced by oncogenic Raf.

10 September 2017

1 reference

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COBRA: a sensitive and quantitative DNA methylation assay

10 September 2017

1 reference

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A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Induced pluripotent stem cells and senescence: learning the biology to improve the technology

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Wild-type and Hupki (human p53 knock-in) murine embryonic fibroblasts: p53/ARF pathway disruption in spontaneous escape from senescence

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Tumour biology: senescence in premalignant tumours

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Insulation of tumor suppressor genes by the nuclear factor CTCF.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

DNA Methylation and Cancer

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592471

2 December 2018

Identifiers

DOI

10.1093/NAR/GKS1051

1 reference

10 September 2017

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10 September 2017

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