From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases (Q39252748)

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English	From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases	scientific article

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scholarly article

1 reference

Europe PubMed Central

10 September 2017

3 references

1 September 2020

5 July 2022

29 July 2022

From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases (English)

1 reference

Europe PubMed Central

10 September 2017

1 reference

based on heuristic

inferred from title

Helicobacter pylori

1 reference

2 November 2019

stomach neoplasm

3 references

1 September 2020

5 July 2022

29 July 2022

Zinc finger protein GLI1

1 reference

22 December 2019

signal transduction

1 reference

26 August 2020

hedgehog protein

1 reference

1 September 2020

1

1 reference

Europe PubMed Central

10 September 2017

4

1 reference

Europe PubMed Central

10 September 2017

author name string

Linda M Krisch

2

1 reference

Europe PubMed Central

10 September 2017

Dominik P Elmer

3

1 reference

Europe PubMed Central

10 September 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

20 April 2017

13 references

Europe PubMed Central

10 September 2017

21 March 2019

3 April 2019

2 August 2019

2 November 2019

20 November 2019

11 December 2019

18 December 2019

22 December 2019

26 August 2020

1 September 2020

5 July 2022

29 July 2022

Cell Communication and Signaling

13 references

Europe PubMed Central

10 September 2017

21 March 2019

3 April 2019

2 August 2019

2 November 2019

20 November 2019

11 December 2019

18 December 2019

22 December 2019

26 August 2020

1 September 2020

5 July 2022

29 July 2022

15

1 reference

Europe PubMed Central

10 September 2017

1

1 reference

Europe PubMed Central

10 September 2017

15

1 reference

Europe PubMed Central

10 September 2017

copyright license

Creative Commons Attribution 4.0 International

12 references

Europe PubMed Central

21 March 2019

Europe PubMed Central

3 April 2019

Europe PubMed Central

2 August 2019

Europe PubMed Central

2 November 2019

Europe PubMed Central

20 November 2019

Europe PubMed Central

11 December 2019

Europe PubMed Central

18 December 2019

Europe PubMed Central

22 December 2019

Europe PubMed Central

26 August 2020

Europe PubMed Central

1 September 2020

Europe PubMed Central

5 July 2022

Europe PubMed Central

29 July 2022

copyright status

0 references

on focus list of Wikimedia project

0 references

https://scigraph.springernature.com/pub.10.1186/s12964-017-0171-4

0 references

Helicobacter pylori: A Paradigm Pathogen for Subverting Host Cell Signal Transmission

1 reference

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Control of inflammation by stromal Hedgehog pathway activation restrains colitis.

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Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.

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Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

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Structural basis of Smoothened regulation by its extracellular domains

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CagA Phosphorylation in Helicobacter pylori-Infected B Cells Is Mediated by the Nonreceptor Tyrosine Kinases of the Src and Abl Families

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Helicobacter pylori Eradication Reduces the Metachronous Recurrence of Gastric Neoplasms by Attenuating the Precancerous Process

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Pathobiology of Helicobacter pylori-Induced Gastric Cancer

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Functional anatomy and physiology of gastric secretion

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Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system

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To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases

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Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.

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10 September 2017

Familial gastric cancer: genetic susceptibility, pathology, and implications for management

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Gastric cancer review

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Efficacy of Hedgehog pathway inhibitors in Basal cell carcinoma

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Helicobacter pylori-induced Sonic Hedgehog expression is regulated by NFκB pathway activation: the use of a novel in vitro model to study epithelial response to infection

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Crosstalks between cytokines and Sonic Hedgehog in Helicobacter pylori infection: a mathematical model

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Gastric secretion

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Stromal response to Hedgehog signaling restrains pancreatic cancer progression

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Canonical and non-canonical Hedgehog signalling and the control of metabolism

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10 September 2017

Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma

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Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy

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G-protein-coupled receptors, Hedgehog signaling and primary cilia

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DNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: a comprehensive profiling approach.

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Interaction between gastric cancer stem cells and the tumor microenvironment

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Helicobacter pylori CagA and gastric cancer: a paradigm for hit-and-run carcinogenesis

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Role of the tumor microenvironment in the pathogenesis of gastric carcinoma

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Unraveling the therapeutic potential of the Hedgehog pathway in cancer

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The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis

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10 September 2017

The acid-secreting parietal cell as an endocrine source of Sonic Hedgehog during gastric repair

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10 September 2017

Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach

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Helicobacter pylori-induced gastric inflammation and gastric cancer

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10 September 2017

Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy

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Morphogen interpretation: the transcriptional logic of neural tube patterning

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The mechanisms of Hedgehog signalling and its roles in development and disease

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Gastric cancer: overview

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High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis

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Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets

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GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.

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The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling

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Hedgehog pathway inhibition and the race against tumor evolution

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Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome

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Efficacy and safety of vismodegib in advanced basal-cell carcinoma.

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The immunoexpression of Shh, Smo and Gli2 in Helicobacter pylori positive and negative gastric biopsies

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The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis.

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c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains

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Intoxication strategy of Helicobacter pylori VacA toxin

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Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells

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Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube

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The Hedgehog's tale: developing strategies for targeting cancer

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Dysregulation of cellular signaling in gastric cancer

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Hedgehog beyond medulloblastoma and basal cell carcinoma

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Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals

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10 September 2017

Non-consensus GLI binding sites in Hedgehog target gene regulation

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Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

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10 September 2017

Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

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10 September 2017

Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium

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10 September 2017

Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice

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Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells

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Virulence mechanisms and persistence strategies of the human gastric pathogen Helicobacter pylori

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Direct cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells.

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Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

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Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

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Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

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Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway

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The primary cilium at the crossroads of mammalian hedgehog signaling

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10 September 2017

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

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Quantitative analysis of the effect of Helicobacter pylori on the expressions of SOX2, CDX2, MUC2, MUC5AC, MUC6, TFF1, TFF2, and TFF3 mRNAs in human gastric carcinoma cells.

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The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

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Hedgehog: functions and mechanisms

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Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori

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10 September 2017

STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

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What lurks beneath: IL-11, via Stat3, promotes inflammation-associated gastric tumorigenesis

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TNF-alpha-inducing protein, a carcinogenic factor secreted from H. pylori, enters gastric cancer cells.

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10 September 2017

Macrophages are mediators of gastritis in acute Helicobacter pylori infection in C57BL/6 mice

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10 September 2017

Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

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10 September 2017

Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer

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10 September 2017

Hedgehog signaling in development and homeostasis of the gastrointestinal tract

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10 September 2017

The Gli code: an information nexus regulating cell fate, stemness and cancer.

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10 September 2017

The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development

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Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

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Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review).

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10 September 2017

Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Fibroblasts in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

GLI transcription factors: mediators of oncogenic Hedgehog signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Helicobacter infection and gastric neoplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Helicobacter pylori outer membrane proteins and gastroduodenal disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Gli3 null mice display glandular overgrowth of the developing stomach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Co-expression of CDX2 and MUC2 in gastric carcinomas: correlations with clinico-pathological parameters and prognosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Communicating with Hedgehogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Helicobacter pylori VacA, a paradigm for toxin multifunctionality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Stromal fibroblasts in cancer initiation and progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Developmental roles and clinical significance of hedgehog signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Helicobacter pylori and gut hormones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Interleukin-1 polymorphisms associated with increased risk of gastric cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Mutations affecting segment number and polarity in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

10 September 2017

Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

14 September 2017

Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

14 September 2017

Direct repression of Sonic Hedgehog expression in the stomach by Cdx2 leads to intestinal transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

14 September 2017

Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

14 September 2017

Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

14 September 2017

Late reactivation of sonic hedgehog by Helicobacter pylori results in population of gastric epithelial cells that are resistant to apoptosis: implication for gastric carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

14 September 2017

Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

14 September 2017

A paracrine requirement for hedgehog signalling in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

14 September 2017

De-regulation of the sonic hedgehog pathway in the InsGas mouse model of gastric carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

14 September 2017

Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

14 September 2017

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

14 September 2017

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

14 September 2017

Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

14 September 2017

Hedgehog Pathway Inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

17 June 2018

Gastric Sonic Hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

17 June 2018

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

17 June 2018

Helicobacter pylori induces NF-kappaB independent of CagA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

17 June 2018

Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

17 June 2018

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

17 June 2018

Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

17 June 2018

Phorbol esters inhibit the Hedgehog signalling pathway downstream of Suppressor of Fused, but upstream of Gli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

17 June 2018

Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

17 June 2018

Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

17 June 2018

Dual degradation signals control Gli protein stability and tumor formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

17 June 2018

Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

17 June 2018

Gastritis promotes an activated bone marrow-derived mesenchymal stem cell with a phenotype reminiscent of a cancer-promoting cell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Helicobacter pylori induces type 4 secretion system-dependent, but CagA-independent activation of IκBs and NF-κB/RelA at early time points.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Helicobacter pylori CagA and VacA genotypes and gastric phenotype: a meta-analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Sonic Hedgehog contributes to gastric mucosal restitution after injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

FOXP3-expressing CD4(+) T-cell numbers increase in areas of duodenal gastric metaplasia and are associated to CD4(+) T-cell aggregates in the duodenum of Helicobacter pylori-infected duodenal ulcer patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Early Helicobacter pylori eradication restores sonic hedgehog expression in the gastric mucosa of Mongolian gerbils.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

CDX2 expression is induced by Helicobacter pylori in AGS cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Reduced Shh expression in TFF2-overexpressing lesions of the gastric fundus under hypochlorhydric conditions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Sonic hedgehog expression in gastric cancer and gastric adenoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Helicobacter pylori-induced atrophic gastritis progressing to gastric cancer exhibits sonic hedgehog loss and aberrant CDX2 expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Sonic hedgehog protein promotes proliferation and chondrogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Meta-analysis of the relationship between cagA seropositivity and gastric cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Hedgehog and patched in neural development and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

21 August 2018

Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397778

4 November 2018

Expression of Cdx2 and hepatocyte antigen in gastric carcinoma: correlation with histologic type and implications for prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28427431

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Re-expression of sonic hedgehog and reduction of CDX2 after Helicobacter pylori eradication prior to incomplete intestinal metaplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/28427431

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/28427431

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of a morphogen (sonic hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils

1 reference

https://pubmed.ncbi.nlm.nih.gov/28427431

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappa B in gastric epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28427431

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of sonic hedgehog and altered methylation of its promoter region in gastric cancer and its related lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/28427431

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of IL-8 production in human gastric epithelial cells by Helicobacter pylori, IL-1beta and TNF-alpha requires tyrosine kinase activity, but not protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/28427431

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gastric cancer originating from bone marrow-derived cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28427431

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Helicobacter pylori eradication restored sonic hedgehog expression in the stomach

1 reference

https://pubmed.ncbi.nlm.nih.gov/28427431

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28427431

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28427431

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eradication of H. pylori did not improve abnormal sonic hedgehog expression in the high risk group for gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28427431

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994

1 reference

https://pubmed.ncbi.nlm.nih.gov/28427431

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8

1 reference

https://pubmed.ncbi.nlm.nih.gov/28427431

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD4(+)CD25(+)CD127(low/-) regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/28427431

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S12964-017-0171-4

1 reference

Europe PubMed Central

10 September 2017

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s12964-017-0171-4

1 reference

Europe PubMed Central

10 September 2017

1 reference

Europe PubMed Central

10 September 2017

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