Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling (Q39259464)

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English	Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

10 September 2017

Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 September 2017

apoptotic process

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based on heuristic

inferred from title

author name string

Ju-Hye Lee

1

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Europe PubMed Central

PubMed publication ID

10 September 2017

Yeong-Seon Won

2

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Europe PubMed Central

PubMed publication ID

10 September 2017

Ki-Hun Park

3

1 reference

Europe PubMed Central

PubMed publication ID

10 September 2017

Mi-Kyung Lee

4

1 reference

Europe PubMed Central

PubMed publication ID

10 September 2017

Hirofumi Tachibana

5

1 reference

Europe PubMed Central

PubMed publication ID

10 September 2017

Koji Yamada

6

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Europe PubMed Central

PubMed publication ID

10 September 2017

Kwon-Il Seo

7

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Europe PubMed Central

PubMed publication ID

10 September 2017

publication date

1 December 2012

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Europe PubMed Central

PubMed publication ID

10 September 2017

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Europe PubMed Central

PubMed publication ID

10 September 2017

17

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Europe PubMed Central

PubMed publication ID

10 September 2017

12

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Europe PubMed Central

PubMed publication ID

10 September 2017

1275-1286

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Europe PubMed Central

PubMed publication ID

10 September 2017

Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule.

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Celastrol inhibits pro-inflammatory cytokine secretion in Crohn's disease biopsies.

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Preclinical studies of celastrol and acetyl isogambogic acid in melanoma.

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A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

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Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice

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Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene Celastrol

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Death by design: mechanism and control of apoptosis

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Caspase-dependent and -independent death pathways in cancer therapy

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Serial killers: ordering caspase activation events in apoptosis

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Apoptosis-inducing factor: a matter of neuron life and death

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Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells.

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Molecular characterization of mitochondrial apoptosis-inducing factor

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Endonuclease G is an apoptotic DNase when released from mitochondria

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Oxidative stress as a mediator of apoptosis

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Celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells

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Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells

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Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors

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Celastrol isolated from Tripterygium regelii induces apoptosis through both caspase-dependent and -independent pathways in human breast cancer cells.

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The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.

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The role of the PI3K-AKT pathway in melanoma

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Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway

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Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

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SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii

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New colorimetric cytotoxicity assay for anticancer-drug screening

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Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA.

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P38 MAPK protects against TNF-alpha-provoked apoptosis in LNCaP prostatic cancer cells.

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6-shogaol (alkanone from ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism

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Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kDa laminin receptor

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Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma model

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The Bcl-2 protein family: arbiters of cell survival

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Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?

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Biochemical pathways of caspase activation during apoptosis

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Bcl-2 family members and apoptosis, taken to heart

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Caspase function in programmed cell death

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The regulation of reactive oxygen species production during programmed cell death

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism.

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Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis

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Neuroprotective effects of bcl-2 overexpression in hippocampal cultures: interactions with pathways of oxidative damage.

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Arachidonic acid-induced apoptosis of human neuroblastoma SK-N-SH cells is mediated through mitochondrial alteration elicited by ROS and Ca(2+)-evoked activation of p38alpha MAPK and JNK1.

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Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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An induced proximity model for caspase-8 activation.

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Celastrol-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-κB activity

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Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways

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Role of reactive oxygen species (ROS) in apoptosis induction

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Mitochondria and apoptosis

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Mitochondrial control of cell death

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Superoxide flashes: early mitochondrial signals for oxidative stress-induced apoptosis

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Caspase-independent cell death: leaving the set without the final cut.

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Wood smoke extract induces oxidative stress-mediated caspase-independent apoptosis in human lung endothelial cells: role of AIF and EndoG.

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Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria

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Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?

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Mitochondrial effectors in caspase-independent cell death

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Identifiers

10.1007/S10495-012-0767-5

1 reference

Europe PubMed Central

PubMed publication ID

10 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 September 2017

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