NEDDylation controls the target specificity of E2F1 and apoptosis induction. (Q39273538)

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8 March 2020

title

NEDDylation controls the target specificity of E2F1 and apoptosis induction (English)

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8 March 2020

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1

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8 March 2020

author name string

M Higuchi

series ordinal

2

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8 March 2020

Y Gotoh

series ordinal

3

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8 March 2020

language of work or name

English

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publication date

24 September 2012

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8 March 2020

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8 March 2020

volume

32

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issue

34

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8 March 2020

page(s)

3954-3964

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Conserved functions of the pRB and E2F families

8 March 2020

cites work

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Life and death decisions by the E2F transcription factors

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Re-evaluating cell-cycle regulation by E2Fs.

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The E2F1-3 transcription factors are essential for cellular proliferation.

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E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells

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Division and apoptosis of E2f-deficient retinal progenitors

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Role of the p53-homologue p73 in E2F1-induced apoptosis

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A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.

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Role for the p53 homologue p73 in E2F-1-induced apoptosis

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Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

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Bim is a direct target of a neuronal E2F-dependent apoptotic pathway.

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Apaf-1 is a transcriptional target for E2F and p53

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Direct coupling of the cell cycle and cell death machinery by E2F.

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Jab1 is a specificity factor for E2F1-induced apoptosis

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Specificity in the activation and control of transcription factor E2F-dependent apoptosis

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E2F1 is crucial for E2F-dependent apoptosis

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E2F3 is a mediator of DNA damage-induced apoptosis

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Chk2 activates E2F-1 in response to DNA damage

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p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2.

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Differential regulation of E2F1 apoptotic target genes in response to DNA damage.

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MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis

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Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series

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Chemotherapy induces NEDP1-mediated destabilization of MDM2.

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The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway

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Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins

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Localization of phosphorylated forms of Bcl-2 in mitosis: co-localization with Ki-67 and nucleolin in nuclear structures and on mitotic chromosomes.

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

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pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

21 January 2018

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Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

21 January 2018

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Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function

21 January 2018

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Ribosomal proteins are targets for the NEDD8 pathway

21 January 2018

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E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation

21 January 2018

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E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8

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Yin Yang 1 induces transcriptional activity of p73 through cooperation with E2F1.

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Specific role for p300/CREB-binding protein-associated factor activity in E2F1 stabilization in response to DNA damage

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Regulation of E2F1 activity by acetylation

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Live or let die: the cell's response to p53

21 January 2018

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A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis

21 January 2018

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Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2.

21 January 2018

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E2F - at the crossroads of life and death

21 January 2018

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A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity.

21 January 2018

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Plat-E: an efficient and stable system for transient packaging of retroviruses

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Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

21 January 2018

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Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFkappaB-dependent transcription

21 January 2018

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E2F Family Members Are Differentially Regulated by Reversible Acetylation

31 March 2020

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E2F-1 functions in mice to promote apoptosis and suppress proliferation

31 March 2020

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Tumor induction and tissue atrophy in mice lacking E2F-1

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2012.428

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23001041%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference