Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress (Q39285948)

10 September 2017

title

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress (English)

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10 September 2017

6

T Helleday

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10 September 2017

R M Jones

1

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10 September 2017

O Mortusewicz

2

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10 September 2017

I Afzal

3

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10 September 2017

M Lorvellec

4

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10 September 2017

P García

5

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10 September 2017

E Petermann

7

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10 September 2017

language of work or name

English

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publication date

3 September 2012

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10 September 2017

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10 September 2017

volume

32

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10 September 2017

issue

32

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10 September 2017

page(s)

3744-3753

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

10 September 2017

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

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Genomic instability--an evolving hallmark of cancer

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To cycle or not to cycle: a critical decision in cancer.

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Nucleotide deficiency promotes genomic instability in early stages of cancer development

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DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'.

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Eukaryotic DNA replication origins: many choices for appropriate answers

21 January 2018

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Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells

21 January 2018

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Replication origin plasticity, Taylor-made: inhibition vs recruitment of origins under conditions of replication stress

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ATR and ATM regulate the timing of DNA replication origin firing

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ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage

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Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

21 January 2018

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ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background

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Chk1 is haploinsufficient for multiple functions critical to tumor suppression

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Chk1 promotes replication fork progression by controlling replication initiation

21 January 2018

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Cyclin E in normal and neoplastic cell cycles

21 January 2018

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Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

21 January 2018

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Transcription-associated recombination is dependent on replication in Mammalian cells

21 January 2018

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R-loop-mediated genomic instability is caused by impairment of replication fork progression

21 January 2018

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Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes

21 January 2018

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Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway.

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Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system

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Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway

21 January 2018

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Deregulation of cyclin E in human cells interferes with prereplication complex assembly

21 January 2018

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Deregulated cyclin E induces chromosome instability

21 January 2018

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Inactivation of hCDC4 can cause chromosomal instability

21 January 2018

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Redundant cyclin overexpression and gene amplification in breast cancer cells

21 January 2018

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Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels.

21 January 2018

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B-Myb is critical for proper DNA duplication during an unperturbed S phase in mouse embryonic stem cells

21 January 2018

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Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase

21 January 2018

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DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells

21 January 2018

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Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells

21 January 2018

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A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

21 January 2018

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BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

21 January 2018

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Human CtIP promotes DNA end resection

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.387

Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.387

Replication fork movement sets chromatin loop size and origin choice in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.387

Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.387

Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.387

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.387

Does interference between replication and transcription contribute to genomic instability in cancer cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.387

The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.387

CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.387

Cyclin-dependent kinases and S phase control in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.387

S-Phase Progression in Synchronized Human Cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.387

Kinase-independent function of cyclin E

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.387

Ectopic expression of cyclin E allows non-endomitotic megakaryoblastic K562 cells to establish re-replication cycles

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.387

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.387

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10 September 2017

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