ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer. (Q39294227)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22907434%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer (English)

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11 February 2020

4

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11 February 2020

Qian Tao

7

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11 February 2020

Enders Kai-on Ng

8

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11 February 2020

Joseph Sung

10

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author name string

W Du

1

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11 February 2020

S Wang

2

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11 February 2020

Q Zhou

3

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11 February 2020

J Chu

5

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11 February 2020

Z Chang

6

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J Fang

9

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J Yu

11

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11 February 2020

language of work or name

English

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publication date

20 August 2012

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11 February 2020

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11 February 2020

volume

32

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issue

28

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page(s)

3319-3328

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https://scigraph.springernature.com/pub.10.1038/onc.2012.359

11 February 2020

exact match

0 references

cites work

Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer.

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Promoter methylation of the Wnt/beta-catenin signaling antagonist Dkk-3 is associated with poor survival in gastric cancer

21 January 2018

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Characterization of the gene structure, functional significance, and clinical application of RNF180, a novel gene in gastric cancer.

21 January 2018

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The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

Paired box gene 5 is a novel tumor suppressor in hepatocellular carcinoma through interaction with p53 signaling pathway

21 January 2018

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Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis

21 January 2018

1 reference

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Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9

21 January 2018

1 reference

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Characterization of a novel epigenetically-silenced, growth-suppressive gene, ADAMTS9, and its association with lymph node metastases in nasopharyngeal carcinoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

ADAMTS9, a novel member of the ADAM-TS/ metallospondin gene family

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

Adamts9 is widely expressed during mouse embryo development.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

mTOR links oncogenic signaling to tumor cell metabolism

21 January 2018

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HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

Overview of cell death signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

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mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.359

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

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Molecular mechanisms of mTOR-mediated translational control

21 January 2018

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Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt.

21 January 2018

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Cyclin D as a therapeutic target in cancer

21 January 2018

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The CDK inhibitors in cancer research and therapy.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

Multiparametric analysis of cells with different mitochondrial membrane potential during apoptosis by polychromatic flow cytometry

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

The Bcl-2 apoptotic switch in cancer development and therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.359

Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.359

Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

Effects of Helicobacter pylori eradication on methylation status of E-cadherin gene in noncancerous stomach.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

CpG methylation and reduced expression of O6-methylguanine DNA methyltransferase is associated with Helicobacter pylori infection

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.359

Cell-surface processing of pro-ADAMTS9 by furin

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/ONC.2012.359

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22907434%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22907434%20AND%20SRC:MED&resulttype=core&format=json