Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb (Q28646935)

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English	Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb	scientific journal article

Statements

scholarly article

1 reference

3 February 2017

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb (English)

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3 February 2017

tuberous sclerosis

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based on heuristic

inferred from title

tuberous sclerosis 1

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based on heuristic

inferred from title

object named as

Andrew R. Tee

1

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ORCID Public Data File 2021

author name string

Brendan D. Manning

2

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3 February 2017

Philippe P. Roux

3

1 reference

3 February 2017

Lewis C. Cantley

4

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3 February 2017

John Blenis

5

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3 February 2017

language of work or name

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publication date

5 August 2003

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3 February 2017

Current Biology

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3 February 2017

13

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3 February 2017

15

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3 February 2017

1259–1268

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3 February 2017

Molecular genetic advances in tuberous sclerosis

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https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

9q34 loss of heterozygosity in a tuberous sclerosis astrocytoma suggests a growth suppressor-like activity also for the TSC1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients.

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https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The tuberous sclerosis gene on chromosome 9q34 acts as a growth suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

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Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

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https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

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https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

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https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

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Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

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https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

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https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

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Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

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https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of both TSC1 and TSC2 for germline mutations in 126 unrelated patients with tuberous sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Coordinate regulation of translation by the PI 3-kinase and mTOR pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Stimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activity

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of translation initiation by FRAP/mTOR

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a conserved motif required for mTOR signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras-effector interactions, the problem of specificity.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Interplay between insulin and nutrients in the regulation of translation factors

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Rheb promotes cell growth as a component of the insulin/TOR signalling network

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

All ras proteins are polyisoprenylated but only some are palmitoylated

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of Ha-ras p21 by substitution, deletion, and insertion mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Rsk1 mediates a MEK-MAP kinase cell survival signal

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Measurement of nucleotide exchange and hydrolysis activities in immunoprecipitates

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https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900506-2

7 January 2021

based on heuristic

inferred from DOI database lookup

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