The hypoxia-inducible factor-C/EBPα axis controls ethanol-mediated hepcidin repression. (Q39301385)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22869521%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

title

The hypoxia-inducible factor-C/EBPα axis controls ethanol-mediated hepcidin repression (English)

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10 February 2020

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3

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10 February 2020

Bishr Omary

6

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10 February 2020

author name string

Erik R Anderson

1

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10 February 2020

Matthew Taylor

2

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10 February 2020

Angelical Martin

4

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10 February 2020

David S Moons

5

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10 February 2020

Yatrik M Shah

7

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10 February 2020

language of work or name

English

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publication date

6 August 2012

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Molecular and Cellular Biology

10 February 2020

published in

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10 February 2020

volume

32

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10 February 2020

issue

19

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10 February 2020

page(s)

4068-4077

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Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis

10 February 2020

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Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis

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C/EBPα Dysregulation in AML and ALL

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Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver

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Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression

10 September 2017

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Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis

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Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice

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Is iron overload in alcohol-related cirrhosis mediated by hepcidin?

10 September 2017

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Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors

10 September 2017

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Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones

10 September 2017

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Is the iron regulatory hormone hepcidin a risk factor for alcoholic liver disease?

10 September 2017

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Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications

10 September 2017

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Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-alpha signaling

10 September 2017

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The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin

10 September 2017

1 reference

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Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

10 September 2017

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Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha

10 September 2017

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10 September 2017

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Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).

10 September 2017

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Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis

10 September 2017

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Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production

10 September 2017

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10 September 2017

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10 September 2017

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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

10 September 2017

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Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis.

10 September 2017

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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

10 September 2017

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Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

10 September 2017

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Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

10 September 2017

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10 September 2017

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Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha

10 September 2017

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10 September 2017

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Liver iron is predictive of death in alcoholic cirrhosis: a multivariate study of 229 consecutive patients with alcoholic and/or hepatitis C virus cirrhosis: a prospective follow up study

10 September 2017

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

10 September 2017

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Downregulating hypoxia-inducible factor-2α improves the efficacy of doxorubicin in the treatment of hepatocellular carcinoma

10 September 2017

1 reference

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Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling

10 September 2017

1 reference

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Transferrin receptor 2 is crucial for iron sensing in human hepatocytes.

14 September 2017

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Activated macrophages induce hepcidin expression in HuH7 hepatoma cells

14 September 2017

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2-Oxoglutarate-dependent oxygenases control hepcidin gene expression

14 September 2017

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Analysis of adenovirus sequestration in the liver, transduction of hepatic cells, and innate toxicity after injection of fiber-modified vectors

14 September 2017

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Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice

25 September 2017

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Hepcidin regulation in wild-type and Hfe knockout mice in response to alcohol consumption: evidence for an alcohol-induced hypoxic response.

17 June 2018

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C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism

17 June 2018

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Synergistic Interaction between Excess Hepatic Iron and Alcohol Ingestion in Hepatic Mutagenesis

17 June 2018

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Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells.

21 August 2018

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Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease.

21 August 2018

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Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload.

21 August 2018

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Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse

21 August 2018

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Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol

21 August 2018

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12 December 2020

Hepcidin is down-regulated in alcohol loading

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12 December 2020

Oxidative stress and alcoholic liver disease

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12 December 2020

Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression

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12 December 2020

Identifiers

DOI

10.1128/MCB.00723-12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22869521%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22869521%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference