Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer (Q39312343)

10 September 2017

Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer (English)

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10 September 2017

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5

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4

Merja Perälä

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10 September 2017

Reetta Virtakoivu

1

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10 September 2017

Teijo Pellinen

series ordinal

2

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10 September 2017

Juha K Rantala

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3

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10 September 2017

18 July 2012

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Molecular Biology of the Cell

10 September 2017

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23

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17

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3357-3369

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describes a project that uses

10 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3431929/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Axl is essential for VEGF-A-dependent activation of PI3K/Akt

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Methods for cell and particle tracking

11 September 2017

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Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo

11 September 2017

1 reference

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SHARPIN is an endogenous inhibitor of β1-integrin activation

11 September 2017

1 reference

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Regulation of integrin activation

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

Cooperation between integrins and growth factor receptors in signaling and endocytosis

11 September 2017

1 reference

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Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

11 September 2017

1 reference

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AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

11 September 2017

1 reference

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Ligand-independent activation of c-Met by fibronectin and α(5)β(1)-integrin regulates ovarian cancer invasion and metastasis

11 September 2017

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MicroRNA-200 family members differentially regulate morphological plasticity and mode of melanoma cell invasion

11 September 2017

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The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration

11 September 2017

1 reference

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Distinct biological roles for the akt family in mammary tumor progression

11 September 2017

1 reference

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The final steps of integrin activation: the end game

11 September 2017

1 reference

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Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance

11 September 2017

1 reference

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Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

11 September 2017

1 reference

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Anti-integrin monoclonal antibodies

11 September 2017

1 reference

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miR-200 enhances mouse breast cancer cell colonization to form distant metastases

11 September 2017

1 reference

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Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

Regulation of integrin activity and signalling

11 September 2017

1 reference

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Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues

11 September 2017

1 reference

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Endocytic transport of integrins during cell migration and invasion.

11 September 2017

1 reference

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Kindlin-3 is essential for integrin activation and platelet aggregation

11 September 2017

1 reference

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Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments

11 September 2017

1 reference

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Functional atlas of the integrin adhesome

11 September 2017

1 reference

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AKT/PKB signaling: navigating downstream

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration.

11 September 2017

1 reference

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Expression and localisation of Akt-1, Akt-2 and Akt-3 correlate with clinical outcome of prostate cancer patients

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition

11 September 2017

1 reference

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Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT

11 September 2017

1 reference

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Akt-regulated pathways in prostate cancer

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

Cell migration in 3D matrix

11 September 2017

1 reference

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MicroRNAs: genomics, biogenesis, mechanism, and function

11 September 2017

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Will mTOR inhibitors make it as cancer drugs?

11 September 2017

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Protein kinase B alpha/Akt1 regulates placental development and fetal growth

11 September 2017

1 reference

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Tumour-cell invasion and migration: diversity and escape mechanisms

11 September 2017

1 reference

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Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells

11 September 2017

1 reference

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A functional genetic screen reveals new regulators of β1-integrin activity

11 September 2017

1 reference

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Distinct recycling of active and inactive β1 integrins

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

The pharmacology of mTOR inhibition

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

Pilot study of rapamycin in patients with hormone-refractory prostate cancer

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

A negative feedback signaling network underlies oncogene-induced senescence

21 August 2018

1 reference

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Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431929

Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival

21 August 2018

1 reference

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Opposing Roles for Akt1 and Akt2 in Rac/Pak Signaling and Cell Migration

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22809628

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Specificities of β1 integrin signaling in the control of cell adhesion and adhesive strength

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22809628

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1091/MBC.E12-03-0213

1 reference

10 September 2017

1 reference

10 September 2017

1 reference