Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages. (Q39321280)

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6 February 2020

title

Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages (English)

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13

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6 February 2020

Andreas Weigert

3

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Maximilian Waldner

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Jörn Lötsch

10

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12

Bernhard Brüne

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9

Gerd Geisslinger

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Annett Häussler

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8

Nerea Ferreirós

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1

Geethanjali Pickert

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5

Thekla Myrczek

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6 February 2020

author name string

Hee-Young Lim

2

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Sandra Labocha

7

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Christoph Becker

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language of work or name

English

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publication date

20 July 2012

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International Journal of Cancer

6 February 2020

number of pages

14

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based on heuristic

inferred from page(s)

published in

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6 February 2020

volume

132

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issue

3

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6 February 2020

page(s)

591-604

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Serum neopterin levels in patients with breast cancer

6 February 2020

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Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation

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Roles of tetrahydrobiopterin in promoting tumor angiogenesis

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Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses

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Nitric oxide, apoptosis and macrophage polarization during tumor progression.

21 January 2018

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A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

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GTP cyclohydrolase I inhibition by the prototypic inhibitor 2, 4-diamino-6-hydroxypyrimidine. Mechanisms and unanticipated role of GTP cyclohydrolase I feedback regulatory protein

21 January 2018

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The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein

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Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses

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Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene

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Involvement of apoptosis and calcium mobilization in tetrahydrobiopterin-induced dopaminergic cell death

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Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain

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Coexpression of GTP cyclohydrolase I and inducible nitric oxide synthase mRNAs in mouse osteoblastic cells activated by proinflammatory cytokines

21 January 2018

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21 January 2018

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21 January 2018

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Tetrahydrobiopterin is a secretory product of murine vascular endothelial cells.

21 January 2018

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Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse

21 January 2018

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Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells

21 January 2018

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Principles of bioactive lipid signalling: lessons from sphingolipids

21 January 2018

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Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate.

21 January 2018

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Human epithelial ovarian carcinoma cell-derived cytokines cooperatively induce activated CD4+CD25-CD45RA+ naïve T cells to express forkhead box protein 3 and exhibit suppressive ability in vitro

21 January 2018

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Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor.

21 January 2018

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Modulating the expression of IFN regulatory factor 8 alters the protumorigenic behavior of CD11b+Gr-1+ myeloid cells

21 January 2018

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