Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. (Q39337756)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446690%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446690%20AND%20SRC:MED&resulttype=core&format=json

phosphatidylinositol 4-kinase beta

18 March 2020

main subject

1 reference

10 September 2018

0 references

12

1 reference

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18 March 2020

Susan A. Charman

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Gerard Drewes

46

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Tanya Paquet

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28

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Iñigo Angulo-Barturen

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author name string

Claire Le Manach

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18 March 2020

language of work or name

English

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publication date

1 April 2017

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Science Translational Medicine

18 March 2020

published in

1 reference

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18 March 2020

volume

9

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18 March 2020

issue

387

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Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

18 March 2020

cites work

1 reference

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30 June 2018

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30 June 2018

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30 June 2018

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Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.

30 June 2018

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30 June 2018

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30 June 2018

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A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

30 June 2018

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30 June 2018

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Lead clinical and preclinical antimalarial drugs can significantly reduce sporozoite transmission to vertebrate populations.

30 June 2018

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Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures

30 June 2018

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KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro

30 June 2018

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Targeting Plasmodium PI(4)K to eliminate malaria

30 June 2018

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In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

30 June 2018

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Primaquine for prophylaxis of malaria: has the CYP sailed?

30 June 2018

1 reference

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Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum

30 June 2018

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Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity

30 June 2018

1 reference

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Culture-adapted Plasmodium falciparum isolates from UK travellers: in vitro drug sensitivity, clonality and drug resistance markers

30 June 2018

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Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

30 June 2018

1 reference

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Designing the next generation of medicines for malaria control and eradication

30 June 2018

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Transmission-blocking interventions eliminate malaria from laboratory populations.

30 June 2018

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Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families

30 June 2018

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Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines

30 June 2018

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A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3

30 June 2018

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Use of a rhesus Plasmodium cynomolgi model to screen for anti-hypnozoite activity of pharmaceutical substances

30 June 2018

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A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation

30 June 2018

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3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential

30 June 2018

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P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-action

30 June 2018

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30 June 2018

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Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue

30 June 2018

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Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta)

30 June 2018

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Large-scale phosphosite quantification in tissues by a spike-in SILAC method.

30 June 2018

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Development, evaluation, and application of an in silico model for antimalarial drug treatment and failure.

30 June 2018

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A framework for variation discovery and genotyping using next-generation DNA sequencing data

30 June 2018

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Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

30 June 2018

1 reference

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Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

30 June 2018

1 reference

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Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery

30 June 2018

1 reference

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The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

30 June 2018

1 reference

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Targeted data acquisition for improved reproducibility and robustness of proteomic mass spectrometry assays

30 June 2018

1 reference

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Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes

30 June 2018

1 reference

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The Sequence Alignment/Map format and SAMtools

30 June 2018

1 reference

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Fast and accurate short read alignment with Burrows-Wheeler transform

30 June 2018

1 reference

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Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

30 June 2018

1 reference

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In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models

30 June 2018

1 reference

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Features of selective kinase inhibitors

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731459

Human malaria parasites in continuous culture

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731459

A combination of new screening assays for prioritization of transmission-blocking antimalarials reveals distinct dynamics of marketed and experimental drugs

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731459

Measuring and managing ratio compression for accurate iTRAQ/TMT quantification.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731459

Drug discovery: Priming the antimalarial pipeline.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731459

Delayed fragmentation and optimized isolation width settings for improvement of protein identification and accuracy of isobaric mass tag quantification on Orbitrap-type mass spectrometers

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28446690

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCITRANSLMED.AAD9735

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446690%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446690%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference