WEE1 accumulation and deregulation of S-phase proteins mediate MLN4924 potent inhibitory effect on Ewing sarcoma cells (Q39340936)

11 September 2017

title

WEE1 accumulation and deregulation of S-phase proteins mediate MLN4924 potent inhibitory effect on Ewing sarcoma cells (English)

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11 September 2017

C Mackintosh

1

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11 September 2017

D J García-Domínguez

2

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11 September 2017

J L Ordóñez

3

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11 September 2017

A Ginel-Picardo

4

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11 September 2017

P G Smith

5

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11 September 2017

M P Sacristán

6

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11 September 2017

E de Álava

7

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11 September 2017

language of work or name

English

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publication date

28 May 2012

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11 September 2017

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11 September 2017

volume

32

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11 September 2017

issue

11

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11 September 2017

page(s)

1441-1451

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Ewing's sarcoma family of tumors: current management

11 September 2017

cites work

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Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins

21 January 2018

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Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

21 January 2018

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M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

21 January 2018

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Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

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Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

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MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma

21 January 2018

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Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort

21 January 2018

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NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells

21 January 2018

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Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover

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Skp2-mediated degradation of p27 regulates progression into mitosis

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Multiple mechanisms for p27(Kip1) translocation and degradation.

21 January 2018

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Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases

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Chk1 and Chk2 kinases in checkpoint control and cancer

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Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6

21 January 2018

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Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

21 January 2018

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Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle.

21 January 2018

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Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

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Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia.

21 January 2018

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Induction of p21-dependent senescence by an NAE inhibitor, MLN4924, as a mechanism of growth suppression

21 January 2018

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Systematic and quantitative assessment of the ubiquitin-modified proteome

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.153

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases

21 January 2018

1 reference

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p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2

21 January 2018

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Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

21 January 2018

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p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

21 January 2018

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CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

21 January 2018

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In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma

21 January 2018

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Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor

21 January 2018

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The value of local treatment in patients with primary, disseminated, multifocal Ewing sarcoma (PDMES)

21 January 2018

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1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.153

Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.153

Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.153

Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.153

Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.153

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.153

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Dimensions Publication ID

11 September 2017

1012274465

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