Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation (Q39358737)

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scientific article published on 22 June 2012

Language	Label	Description	Also known as
English	Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation	scientific article published on 22 June 2012

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scholarly article

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Europe PubMed Central

11 September 2017

Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation (English)

1 reference

Europe PubMed Central

11 September 2017

5

object named as

Dana Gabuzda

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Europe PubMed Central

11 September 2017

3

object named as

Vikas Misra

1 reference

Europe PubMed Central

11 September 2017

author name string

Joya Mukerji

1

1 reference

Europe PubMed Central

11 September 2017

Kevin C Olivieri

2

1 reference

Europe PubMed Central

11 September 2017

Kristin A Agopian

4

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Europe PubMed Central

11 September 2017

publication date

22 June 2012

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Europe PubMed Central

11 September 2017

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Europe PubMed Central

11 September 2017

9

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Europe PubMed Central

11 September 2017

33

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Europe PubMed Central

11 September 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3382630/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

https://scigraph.springernature.com/pub.10.1186/1742-4690-9-33

0 references

Global landscape of HIV-human protein complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

Cell polarity during motile processes: keeping on track with the exocyst complex.

1 reference

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11 September 2017

The immunological synapse: a focal point for endocytosis and exocytosis

1 reference

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11 September 2017

Optimized methods for imaging membrane nanotubes between T cells and trafficking of HIV-1.

1 reference

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11 September 2017

Genetic characterization of HIV type 1 Nef-induced vesicle secretion

1 reference

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An emerging role for p21-activated kinases (Paks) in viral infections

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Implications of Nef: host cell interactions in viral persistence and progression to AIDS.

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11 September 2017

RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling

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11 September 2017

Intraflagellar transport: it's not just for cilia anymore

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11 September 2017

HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells

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The Universal Protein Resource (UniProt) in 2010

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11 September 2017

The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.

1 reference

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11 September 2017

Pathways and mechanisms of endocytic recycling

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11 September 2017

HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits

1 reference

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11 September 2017

Defining the human deubiquitinating enzyme interaction landscape

1 reference

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11 September 2017

Membrane vesicles as conveyors of immune responses

1 reference

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11 September 2017

The exocyst complex in polarized exocytosis

1 reference

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11 September 2017

Tunnelling nanotubes: a highway for prion spreading?

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11 September 2017

A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication

1 reference

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11 September 2017

Exosomes--vesicular carriers for intercellular communication

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11 September 2017

Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

Avoiding the void: cell-to-cell spread of human viruses

1 reference

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11 September 2017

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

HIV-1 Nef: at the crossroads

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

HIV-1 at the immunological and T-lymphocytic virological synapse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

Cytonemes and tunneling nanotubules in cell-cell communication and viral pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

Identification of host proteins required for HIV infection through a functional genomic screen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

Modulation of the immunological synapse: a key to HIV-1 pathogenesis?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

Distinct transcriptional profiles in ex vivo CD4+ and CD8+ T cells are established early in human immunodeficiency virus type 1 infection and are characterized by a chronic interferon response as well as extensive transcriptional changes in CD8+ T c

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

The exocyst defrocked, a framework of rods revealed.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

STRING: known and predicted protein-protein associations, integrated and transferred across organisms

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11 September 2017

Sec15 is an effector for the Rab11 GTPase in mammalian cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

In vivo analysis of Nef function

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11 September 2017

Human immunodeficiency virus type 1 Nef associates with lipid rafts to downmodulate cell surface CD4 and class I major histocompatibility complex expression and to increase viral infectivity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis

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11 September 2017

Ral GTPases regulate exocyst assembly through dual subunit interactions

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11 September 2017

Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinase

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11 September 2017

Hide, shield and strike back: how HIV-infected cells avoid immune eradication

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11 September 2017

HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway

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11 September 2017

Nef is required for efficient HIV-1 replication in cocultures of dendritic cells and lymphocytes.

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11 September 2017

Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators

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11 September 2017

Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

Lentivirus Nef specifically activates Pak2.

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11 September 2017

Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif

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11 September 2017

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

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11 September 2017

Activation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complex

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11 September 2017

Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

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11 September 2017

HIV-1 Nef increases T cell activation in a stimulus-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

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11 September 2017

Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

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11 September 2017

Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382630

11 September 2017

HIV Type 1 Nef is released from infected cells in CD45(+) microvesicles and is present in the plasma of HIV-infected individuals

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14 September 2017

M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex

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14 September 2017

Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA

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14 September 2017

Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B.

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14 September 2017

HIV-1 Nef protein is secreted into vesicles that can fuse with target cells and virions

1 reference

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14 September 2017

Sustained expression of alpha1-antitrypsin after transplantation of manipulated hematopoietic stem cells.

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14 September 2017

Expression of simian immunodeficiency virus Nef protein in CD4+ T cells leads to a molecular profile of viral persistence and immune evasion

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14 September 2017

Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1.

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14 September 2017

Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity

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14 September 2017

Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts.

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14 September 2017

A novel role for p21-activated protein kinase 2 in T cell activation

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14 September 2017

Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts

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14 September 2017

The exocyst affects protein synthesis by acting on the translocation machinery of the endoplasmic reticulum

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14 September 2017

Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity

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17 June 2018

The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity

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17 June 2018

Exo70 interacts with the Arp2/3 complex and regulates cell migration

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21 August 2018

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

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21 August 2018

Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement

1 reference

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21 August 2018

Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction

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21 August 2018

Vav exchange factor counteracts the HIV-1 Nef-mediated decrease of plasma membrane GM1 and NF-AT activity in T cells.

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21 August 2018

TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex

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21 August 2018

Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T-cell lymphoma cell line

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21 August 2018

Intrusive HIV-1-infected cells

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21 January 2018

Interaction between Nef and phosphatidylinositol-3-kinase leads to activation of p21-activated kinase and increased production of HIV

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nef: out and in?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22534017

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-1 Nef induces a Rab11-dependent routing of endocytosed immune costimulatory proteins CD80 and CD86 to the Golgi

1 reference

https://pubmed.ncbi.nlm.nih.gov/22534017

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome-scale RNAi screen for host factors required for HIV replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/22534017

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Navigating the deubiquitinating proteome with a CompPASS

1 reference

https://pubmed.ncbi.nlm.nih.gov/22534017

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22534017

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1742-4690-9-33

1 reference

Europe PubMed Central

11 September 2017

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

11 September 2017

1 reference

Europe PubMed Central

11 September 2017

ResearchGate publication ID

0 references

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