The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity (Q43756172)

26 November 2017

The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity (English)

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26 November 2017

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Oliver T Fackler

7

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author name string

Claudia Haller

1

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26 November 2017

Susanne Rauch

2

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26 November 2017

Nico Michel

3

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26 November 2017

Sebastian Hannemann

4

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26 November 2017

Maik J Lehmann

5

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26 November 2017

Oliver T Keppler

6

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26 November 2017

language of work or name

English

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publication date

10 May 2006

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Journal of Biological Chemistry

26 November 2017

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26 November 2017

281

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26 November 2017

19618-19630

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26 November 2017

28

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Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

26 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Nef: agent of cell subversion

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513802200

Structure--function relationships in HIV-1 Nef.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

HIV-1 Nef increases T cell activation in a stimulus-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

The N-Terminus of Nef from HIV-1/SIV Associates with a Protein Complex Containing Lck and a Serine Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Interaction networks in yeast define and enumerate the signaling steps of the vertebrate aryl hydrocarbon receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

The immunological synapse balances T cell receptor signaling and degradation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513802200

Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513802200

Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513802200

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513802200

Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Tyrosine-phosphorylated T cell receptor ζ chain associates with the actin cytoskeleton upon Activation of mature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Construction and characterization of a fluorescently labeled infectious human immunodeficiency virus type 1 derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Disruption of the actin cytoskeleton can complement the ability of Nef to enhance human immunodeficiency virus type 1 infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Activation of the Rac-binding partner FHOD1 induces actin stress fibers via a ROCK-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

HIV-1 Nef triggers Vav-mediated signaling pathway leading to functional and morphological differentiation of dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Interplay between TCR signalling and actin cytoskeleton dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

p21-activated kinase 1 plays a critical role in cellular activation by Nef.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Identification of the Nef-associated kinase as p21-activated kinase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Cell migration at a glance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

TCR engagement induces proline-rich tyrosine kinase-2 (Pyk2) translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Actin depolymerization transduces the strength of B-cell receptor stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Human endothelial cells enhance human immunodeficiency virus type 1 replication in CD4+ T cells in a Nef-dependent manner in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

The decreased replicative capacity of simian immunodeficiency virus SIVmac239Delta(nef) is manifest in cultures of immature dendritic cellsand T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Human immunodeficiency virus type 1 Nef domains required for disruption of major histocompatibility complex class I trafficking are also necessary for coprecipitation of Nef with HLA-A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

Actin Assembly and Endocytosis: From Yeast to Mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513802200

21 January 2018

Identifiers

DOI

10.1074/JBC.M513802200

1 reference

26 November 2017

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