A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2 (Q36424087)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18032517%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

title

A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2 (English)

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27 December 2019

6

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27 December 2019

author name string

O Wolf Lindwasser

1

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27 December 2019

William J Smith

2

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27 December 2019

Rittik Chaudhuri

3

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27 December 2019

Peter Yang

4

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27 December 2019

James H Hurley

5

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27 December 2019

language of work or name

English

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publication date

21 November 2007

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27 December 2019

number of pages

9

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based on heuristic

inferred from page(s)

published in

Journal of Virology

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27 December 2019

volume

82

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27 December 2019

page(s)

1166-1174

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27 December 2019

issue

3

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HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2.

27 December 2019

cites work

1 reference

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The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope

30 September 2017

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The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site

30 September 2017

1 reference

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Mechanisms of CD4 downregulation by the Nef and Vpu proteins of primate immunodeficiency viruses

30 September 2017

1 reference

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Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.

30 September 2017

1 reference

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Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways

30 September 2017

1 reference

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Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motif

30 September 2017

1 reference

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Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

30 September 2017

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Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes

30 September 2017

1 reference

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HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent

30 September 2017

1 reference

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Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta

30 September 2017

1 reference

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Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes

30 September 2017

1 reference

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CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms.

30 September 2017

1 reference

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HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail

30 September 2017

1 reference

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Adaptors for clathrin coats: structure and function.

30 September 2017

1 reference

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Adaptable adaptors for coated vesicles

30 September 2017

1 reference

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Role of CD4 receptor down-regulation during HIV-1 infection

30 September 2017

1 reference

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The physiological relevance of CD4 receptor down-modulation during HIV infection

30 September 2017

1 reference

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HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane

30 September 2017

1 reference

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Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 gamma-sigma1 and AP-3 delta-sigma3 hemicomplexes

30 September 2017

1 reference

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Signals for sorting of transmembrane proteins to endosomes and lysosomes

30 September 2017

1 reference

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Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis

30 September 2017

1 reference

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HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

Nef: agent of cell subversion

30 September 2017

1 reference

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Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein

30 September 2017

1 reference

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Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

30 September 2017

1 reference

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A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4

30 September 2017

1 reference

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A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor

30 September 2017

1 reference

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Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

30 September 2017

1 reference

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Binding of c-Raf1 kinase to a conserved acidic sequence within the carboxyl-terminal region of the HIV-1 Nef protein

30 September 2017

1 reference

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Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4

30 September 2017

1 reference

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Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

30 September 2017

1 reference

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The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes

30 September 2017

1 reference

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Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation

30 September 2017

1 reference

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Nef-mediated clathrin-coated pit formation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

Refined solution structure and backbone dynamics of HIV-1 Nef.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

Nef-CD4 physical interaction sensed with the yeast two-hybrid system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

Myristoylation-dependent binding of HIV-1 Nef to CD4.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

The human immunodeficiency virus type 1 Vpu protein specifically binds to the cytoplasmic domain of CD4: implications for the mechanism of degradation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans-Golgi network localization and internalization from the cell surface

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

Amino acid substitution matrices from protein blocks

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

Dynamic interaction of HIV-1 Nef with the clathrin-mediated endocytic pathway at the plasma membrane.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2224420

HIV-1 Nef disrupts antigen presentation early in the secretory pathway

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18032517

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/JVI.01874-07

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18032517%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18032517%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference