Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1. (Q39411406)

11 September 2017

Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1. (English)

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11 September 2017

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A Fassl

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K E Tagscherer

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J Richter

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M Berriel Diaz

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S R Alcantara Llaguno

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B Campos

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J Kopitz

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C Herold-Mende

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M H H Schmidt

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L F Parada

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O D Wiestler

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W Roth

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11 September 2017

language of work or name

English

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publication date

16 January 2012

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31

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4698-4708

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https://scigraph.springernature.com/pub.10.1038/onc.2011.615

11 September 2017

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cites work

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Contribution of Notch signaling activation to human glioblastoma multiforme.

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Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells

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The oncogenic roles of Notch1 in astrocytic gliomas in vitro and in vivo

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Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis.

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Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation

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Mitochondrial DNA integrity is essential for mitochondrial maturation during differentiation of neural stem cells

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Identification of human brain tumour initiating cells

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Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

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Neural stem cells and the origin of gliomas

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Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

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A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration

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Differentiation therapy exerts antitumor effects on stem-like glioma cells

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

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Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma

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A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

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Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

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Mcl-1; the molecular regulation of protein function

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Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells

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Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

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Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

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Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress

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Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin.

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Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway

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A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications

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Notch-1 regulates transcription of the epidermal growth factor receptor through p53.

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ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

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Increased expression of Mcl-1 is responsible for the blockage of TRAIL-induced apoptosis mediated by EGF/ErbB1 signaling pathway

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Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins

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Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation

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Notch, neural stem cells, and brain tumors.

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Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression

21 January 2018

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Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage

21 January 2018

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Mcl-1 degradation during hepatocyte lipoapoptosis

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The regulatory domain of protein kinase Ctheta localises to the Golgi complex and induces apoptosis in neuroblastoma and Jurkat cells

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Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.

21 January 2018

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Different angiogenic phenotypes in primary and secondary glioblastomas

21 January 2018

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Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal

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Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity.

21 January 2018

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Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53

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Arbiter of differentiation and death: Notch signaling meets apoptosis

31 March 2020

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Unraveling MCL-1 degradation

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2011.615

1 reference

11 September 2017

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