mTORC1 inhibition and ECM-cell adhesion-independent drug resistance via PI3K-AKT and PI3K-RAS-MAPK feedback loops (Q39411901)

11 September 2017

title

mTORC1 inhibition and ECM-cell adhesion-independent drug resistance via PI3K-AKT and PI3K-RAS-MAPK feedback loops (English)

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11 September 2017

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Karina Galoian

1

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11 September 2017

H T Temple

series ordinal

2

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11 September 2017

Armen Galoyan

series ordinal

3

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11 September 2017

language of work or name

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14 January 2012

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11 September 2017

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11 September 2017

volume

33

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11 September 2017

issue

3

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11 September 2017

page(s)

885-890

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Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors

11 September 2017

cites work

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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Neurochemistry of brain neuroendocrine immune system: signal molecules

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Myc-oncogene inactivating effect by proline rich polypeptide (PRP-1) in chondrosarcoma JJ012 cells

21 January 2018

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Antitumorigenic effect of brain proline rich polypeptide-1 in human chondrosarcoma

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Cytostatic effect of the hypothalamic cytokine PRP-1 is mediated by mTOR and cMyc inhibition in high grade chondrosarcoma

21 January 2018

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Cytostatic effect of novel mTOR inhibitor, PRP-1 (galarmin) in MDA 231 (ER-) breast carcinoma cell line. PRP-1 inhibits mesenchymal tumors

21 January 2018

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Activation of the PI3K/Akt pathway and chemotherapeutic resistance

21 January 2018

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Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.

21 January 2018

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Hsp27 promotes insulin-like growth factor-I survival signaling in prostate cancer via p90Rsk-dependent phosphorylation and inactivation of BAD.

21 January 2018

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Rsk1 mediates a MEK-MAP kinase cell survival signal

21 January 2018

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CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy

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Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

21 January 2018

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Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells

21 January 2018

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GSK3beta is a negative regulator of the transcriptional coactivator MAML1.

21 January 2018

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Novel agents on the horizon for cancer therapy

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Abrogation of MAPK and Akt signaling by AEE788 synergistically potentiates histone deacetylase inhibitor-induced apoptosis through reactive oxygen species generation

21 January 2018

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Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development

21 January 2018

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Invasive and noninvasive uveal melanomas have different adhesive properties

21 January 2018

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Intercellular adhesion and cancer invasion: a discrete simulation using the extended Potts model.

21 January 2018

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Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts

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Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines

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12 December 2020

Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expression

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12 December 2020

Cell adhesion to the extracellular matrix protein fibronectin modulates radiation-dependent G2 phase arrest involving integrin-linked kinase (ILK) and glycogen synthase kinase-3beta (GSK-3beta) in vitro

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12 December 2020

The dual PI3K/mTOR inhibitor PI-103 promotes immunosuppression, in vivo tumor growth and increases survival of sorafenib-treated melanoma cells.

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12 December 2020

Soluble integrin ligands and growth factors independently rescue neuroblastoma cells from apoptosis under nonadherent conditions

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12 December 2020

Mouse proximal tubular cell-cell adhesion inhibits apoptosis by a cadherin-dependent mechanism

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12 December 2020

Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma.

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12 December 2020

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

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12 December 2020

Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines

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12 December 2020

Histone deacetylase inhibitor PCI-24781 enhances chemotherapy-induced apoptosis in multidrug-resistant sarcoma cell lines

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12 December 2020

Cotargeting survival signaling pathways in cancer

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12 December 2020

Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention

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12 December 2020

10.1007/S13277-011-0315-X

Identifiers

DOI

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11 September 2017

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