TDP-43 toxicity is mediated by the unfolded protein response-unrelated induction of C/EBP homologous protein expression (Q39447231)

12 September 2017

title

TDP-43 toxicity is mediated by the unfolded protein response-unrelated induction of C/EBP homologous protein expression (English)

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2

Masaaki Matsuoka

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Hiroaki Suzuki

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publication date

4 November 2011

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Journal of Neuroscience Research

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published in

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volume

90

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issue

3

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page(s)

641-647

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TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

12 September 2017

cites work

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Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

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Review: transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration

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Nitric oxide and endoplasmic reticulum stress

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Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)

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ER stress and unfolded protein response in amyotrophic lateral sclerosis

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Elevated gadd153/chop expression and enhanced c-Jun N-terminal protein kinase activation sensitizes aged cells to ER stress

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Endoplasmic reticulum stress in disease pathogenesis

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

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Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice

21 January 2018

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Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

21 January 2018

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ER stress triggers apoptosis by activating BH3-only protein Bim

21 January 2018

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Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management

21 January 2018

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Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

21 January 2018

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Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

21 January 2018

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ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB.

21 January 2018

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TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage

21 January 2018

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Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

21 January 2018

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Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.

21 January 2018

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Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

21 January 2018

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Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells.

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

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ER stress and diseases.

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21 January 2018

Identifiers

DOI

10.1002/JNR.22777

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12 September 2017

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