Phosphatase and tensin homolog regulates the pluripotent state and lineage fate choice in human embryonic stem cells. (Q39467874)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948699%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Phosphatase and tensin homolog regulates the pluripotent state and lineage fate choice in human embryonic stem cells (English)

1 reference

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13 February 2020

1 reference

human embryonic stem cell

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2

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13 February 2020

author name string

Jackelyn A Alva

series ordinal

1

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13 February 2020

Erika E Escobar

series ordinal

3

1 reference

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13 February 2020

April D Pyle

series ordinal

4

1 reference

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13 February 2020

publication date

1 December 2011

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13 February 2020

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13 February 2020

volume

29

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13 February 2020

issue

12

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13 February 2020

page(s)

1952-1962

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Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling

13 February 2020

cites work

1 reference

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Control of the embryonic stem cell state

12 September 2017

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Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog

12 September 2017

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mTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells

12 September 2017

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Pax6 is a human neuroectoderm cell fate determinant

12 September 2017

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Extrinsic regulation of pluripotent stem cells

12 September 2017

1 reference

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Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

12 September 2017

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Direct conversion of fibroblasts to functional neurons by defined factors

12 September 2017

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A continuum of cell states spans pluripotency and lineage commitment in human embryonic stem cells

12 September 2017

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Inhibition of caspase-mediated anoikis is critical for basic fibroblast growth factor-sustained culture of human pluripotent stem cells

12 September 2017

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Naive and primed pluripotent states

12 September 2017

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Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling

12 September 2017

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mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells

12 September 2017

1 reference

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A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors

12 September 2017

1 reference

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Integrated chemical genomics reveals modifiers of survival in human embryonic stem cells

12 September 2017

1 reference

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Transcriptional regulatory networks in embryonic stem cells

12 September 2017

1 reference

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Integration of external signaling pathways with the core transcriptional network in embryonic stem cells

12 September 2017

1 reference

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The ground state of embryonic stem cell self-renewal

12 September 2017

1 reference

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T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways

12 September 2017

1 reference

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Tenets of PTEN tumor suppression

12 September 2017

1 reference

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AKT/PKB signaling: navigating downstream

12 September 2017

1 reference

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Transcriptional analysis of early lineage commitment in human embryonic stem cells

12 September 2017

1 reference

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PTEN-deficient intestinal stem cells initiate intestinal polyposis

12 September 2017

1 reference

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Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1

12 September 2017

1 reference

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

12 September 2017

1 reference

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Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898662

Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features

12 September 2017

1 reference

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PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry

12 September 2017

1 reference

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12 September 2017

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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

12 September 2017

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PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

12 September 2017

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Pten is essential for embryonic development and tumour suppression

12 September 2017

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Phosphorylation of Sox2 cooperates in reprogramming to pluripotent stem cells

12 September 2017

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FGF-2 modulates Wnt signaling in undifferentiated hESC and iPS cells through activated PI3-K/GSK3beta signaling

14 September 2017

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IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro.

14 September 2017

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Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors.

14 September 2017

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Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling.

14 September 2017

1 reference

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Dysregulated gene expression during hematopoietic differentiation from human embryonic stem cells

14 September 2017

1 reference

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The phosphoinositide-3-kinase/Akt pathway mediates the transient increase in Nanog expression during differentiation of F9 cells

15 June 2018

1 reference

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Localized decrease of beta-catenin contributes to the differentiation of human embryonic stem cells

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898662

Anti-apoptotic effect of sphingosine-1-phosphate and platelet-derived growth factor in human embryonic stem cells.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898662

Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898662

The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis.

21 August 2018

1 reference

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Neurotrophins mediate human embryonic stem cell survival

21 August 2018

1 reference

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Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898662

WNT/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells.

21 August 2018

1 reference

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Enrichment of neurons and neural precursors from human embryonic stem cells.

21 August 2018

1 reference

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Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo

21 August 2018

1 reference

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Regulation of Nanog Expression by Phosphoinositide 3-Kinase-dependent Signaling in Murine Embryonic Stem Cells

21 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FSTEM.748

Pleiotrophin enhances clonal growth and long-term expansion of human embryonic stem cells

21 January 2018

1 reference

12 December 2020

A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation

1 reference

12 December 2020

Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/beta-catenin, Activin/Nodal and BMP signaling

1 reference

12 December 2020

Different flavors of pluripotency, molecular mechanisms, and practical implications

1 reference

12 December 2020

Identifiers

DOI

10.1002/STEM.748

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948699%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948699%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

21948699

1 reference