Functional characterization of a novel FGFR2 mutation, E731K, in craniosynostosis (Q39471985)

12 September 2017

Functional characterization of a novel FGFR2 mutation, E731K, in craniosynostosis (English)

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12 September 2017

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Tae-Joon Cho

6

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author name string

Jounghyen Park

1

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12 September 2017

Ok-Jin Park

2

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12 September 2017

Won-Joon Yoon

3

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12 September 2017

Hyun-Jung Kim

4

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12 September 2017

Kang-Young Choi

5

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12 September 2017

Hyun-Mo Ryoo

7

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12 September 2017

1 February 2012

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Journal of Cellular Biochemistry

12 September 2017

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12 September 2017

113

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12 September 2017

2

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12 September 2017

457-464

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Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

12 September 2017

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Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand

21 January 2018

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P253R fibroblast growth factor receptor-2 mutation induces RUNX2 transcript variants and calvarial osteoblast differentiation

21 January 2018

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Identical mutations in three different fibroblast growth factor receptor genes in autosomal dominant craniosynostosis syndromes

21 January 2018

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Activation of extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2) by FGF-2 and PDGF-BB in normal human osteoblastic and bone marrow stromal cells: differences in mobility and in-gel renaturation of ERK1 in human, rat, and mouse osteoblast

21 January 2018

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Growth pattern in the Apert syndrome

21 January 2018

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Fibroblast growth factor-2 (FGF-2) increases N-cadherin expression through protein kinase C and Src-kinase pathways in human calvaria osteoblasts

21 January 2018

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A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis.

21 January 2018

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Cellular signaling by fibroblast growth factor receptors

21 January 2018

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Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome

21 January 2018

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Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2

21 January 2018

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Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis

21 January 2018

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The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2

21 January 2018

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Erk pathway and activator protein 1 play crucial roles in FGF2-stimulated premature cranial suture closure

21 January 2018

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Establishment and characterization of a stable cell line to evaluate cellular Runx2 activity

21 January 2018

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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

21 January 2018

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Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: roles for Ras and Src

21 January 2018

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Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk

21 January 2018

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Increased osteoblast apoptosis in apert craniosynostosis: role of protein kinase C and interleukin-1.

21 January 2018

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p38 mitogen-activated protein kinase activation is required for fibroblast growth factor-2-stimulated cell proliferation but not differentiation

21 January 2018

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Fibroblast growth factor receptor 2 promotes osteogenic differentiation in mesenchymal cells via ERK1/2 and protein kinase C signaling

21 January 2018

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Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction

21 January 2018

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FGF signaling in the developing endochondral skeleton

21 January 2018

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FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease

21 January 2018

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Fibroblast growth factors

21 January 2018

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FGF2-activated ERK mitogen-activated protein kinase enhances Runx2 acetylation and stabilization

21 January 2018

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Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

21 January 2018

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Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome

21 January 2018

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Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes

21 January 2018

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Cell signaling by receptor tyrosine kinases

21 January 2018

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Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

21 January 2018

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A soluble form of fibroblast growth factor receptor 2 (FGFR2) with S252W mutation acts as an efficient inhibitor for the enhanced osteoblastic differentiation caused by FGFR2 activation in Apert syndrome

21 January 2018

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Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse.

21 January 2018

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Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation

21 January 2018

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Craniosynostosis: genes and mechanisms

21 January 2018

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Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome

21 January 2018

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A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis

21 January 2018

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Genomic organization of the human fibroblast growth factor receptor 2 (FGFR2) gene and comparative analysis of the human FGFR gene family

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.23368

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release_57cq2mihnbdpdgxurvzd6cag7e

12 September 2017

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