Predicting in vivo safety characteristics using physiochemical properties and in vitro assays (Q39481089)

12 September 2017

Predicting in vivo safety characteristics using physiochemical properties and in vitro assays (English)

1 reference

12 September 2017

Nigel Greene

1

1 reference

PubMed ID

21882943

12 September 2017

Minghu Song

series ordinal

2

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12 September 2017

1 September 2011

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Future Medicinal Chemistry

12 September 2017

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12 September 2017

3

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12 September 2017

12

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12 September 2017

1503-1511

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Can the pharmaceutical industry reduce attrition rates?

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP

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Predictivity and reliability of QSAR models: the case of mutagens and carcinogens.

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1 reference

In Silico Screening of Chemicals for Genetic Toxicity Using MDL-QSAR, Nonparametric Discriminant Analysis, E-State, Connectivity, and Molecular Property Descriptors.

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A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software

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1 reference

Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action-Based Predictions of Chemical Carcinogenesis in Rodents.

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1 reference

Cationic amphiphilic drug-induced phospholipidosis

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The influence of drug-like concepts on decision-making in medicinal chemistry

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Physicochemical drug properties associated with in vivo toxicological outcomes: a review

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Toxicity testing in the 21st century: a vision and a strategy.

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Toxicity testing in the 21st century: implications for human health risk assessment

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1 reference

Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

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1 reference

Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential.

21 January 2018

1 reference

21 January 2018

1 reference

Modeling HERG and its interactions with drugs: recent advances in light of current potassium channel simulations

21 January 2018

1 reference

A predictive ligand-based Bayesian model for human drug-induced liver injury

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1 reference

Prediction of drug-related cardiac adverse effects in humans--B: use of QSAR programs for early detection of drug-induced cardiac toxicities

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1 reference

Prediction of drug-related cardiac adverse effects in humans--A: creation of a database of effects and identification of factors affecting their occurrence

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1 reference

Is it possible to more accurately predict which drug candidates will cause idiosyncratic drug reactions?

21 January 2018

1 reference

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

21 January 2018

1 reference

Investigation of a hepatotoxicity screening system in primary cell cultures --"what biomarkers would need to be addressed to estimate toxicity in conventional and new approaches?".

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1 reference

The significance of mitochondrial toxicity testing in drug development

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1 reference

Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development

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1 reference

In vitro evaluation of potential hepatotoxicity induced by drugs.

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1 reference

Managing the challenge of chemically reactive metabolites in drug development.

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1 reference

Cell based approaches for evaluation of drug-induced liver injury.

21 January 2018

1 reference

Predictive value of in vitro safety studies

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1 reference

In vitro safety pharmacology profiling: what else beyond hERG?

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1 reference

Metabolites in safety testing (MIST): considerations of mechanisms of toxicity with dose, abundance, and duration of treatment

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The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform

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Drug-induced mitochondrial toxicity

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Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?

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Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential

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1 reference

Application of a high-content multiparameter cytotoxicity assay to prioritize compounds based on toxicity potential in humans

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Toxicology for the twenty-first century

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Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications

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Serotonergic drugs and valvular heart disease

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1 reference

Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development

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Modeling promiscuity based on in vitro safety pharmacology profiling data

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1 reference

Multi-pathway cellular analysis of compound selectivity

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1 reference

Endocrine profiling and prioritization of environmental chemicals using ToxCast data

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1 reference

A gene expression signature that predicts the future onset of drug-induced renal tubular toxicity

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1 reference

Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: possible implications for toxicogenomics use of in vitro systems

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1 reference

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Identifiers

DOI

10.4155/FMC.11.89

1 reference

12 September 2017

1 reference

PubMed ID

21882943