Transcriptional enhancers induce insertional gene deregulation independently from the vector type and design. (Q39506519)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19293778%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

title

Transcriptional enhancers induce insertional gene deregulation independently from the vector type and design (English)

1 reference

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23 January 2020

7

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23 January 2020

Maria Chiara Bonini

10

1 reference

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23 January 2020

Fulvio Mavilio

12

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23 January 2020

Alessandra Recchia

13

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23 January 2020

author name string

Giulietta Maruggi

1

1 reference

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23 January 2020

Simona Porcellini

2

1 reference

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23 January 2020

Giulia Facchini

3

1 reference

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23 January 2020

Serena K Perna

4

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23 January 2020

Daniela Sartori

6

1 reference

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23 January 2020

Christopher Baum

9

1 reference

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23 January 2020

Chiara Bovolenta

11

1 reference

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23 January 2020

Claudia Cattoglio

5

1 reference

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23 January 2020

Axel Schambach

8

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23 January 2020

publication date

17 March 2009

1 reference

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23 January 2020

1 reference

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23 January 2020

volume

17

1 reference

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23 January 2020

issue

5

1 reference

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23 January 2020

page(s)

851-856

1 reference

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Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

23 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Hot spots of retroviral integration in human CD34+ hematopoietic cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Site-specific integration into the human genome: ready for clinical application?

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Genome-wide analysis of retroviral DNA integration

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Transcription start regions in the human genome are favored targets for MLV integration

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

BLAT—The BLAST-Like Alignment Tool

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Physiological promoters reduce the genotoxic risk of integrating gene vectors

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Correction of laminin-5 deficiency in human epidermal stem cells by transcriptionally targeted lentiviral vectors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Retroviral integration and human gene therapy

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Detection and direct genomic sequencing of multiple rare unknown flanking DNA in highly complex samples

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835143

Murine leukemia induced by retroviral gene marking

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19293778

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Safety of retroviral gene marking with a truncated NGF receptor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19293778

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Globin Lentiviral Vector Insertions Can Perturb the Expression of Endogenous Genes in β-thalassemic Hematopoietic Cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19293778

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/MT.2009.51

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19293778%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

1 reference

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23 January 2020

PubMed publication ID

19293778

1 reference