Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-κB in colon cancer cells (Q39523519)

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scientific article published on 15 June 2011

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English	Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-κB in colon cancer cells	scientific article published on 15 June 2011

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scholarly article

1 reference

Europe PubMed Central

12 September 2017

Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-κB in colon cancer cells (English)

1 reference

Europe PubMed Central

12 September 2017

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author name string

Suboj Babykutty

1

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Europe PubMed Central

12 September 2017

Priya P S

2

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Europe PubMed Central

12 September 2017

Nandini R J

3

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Europe PubMed Central

12 September 2017

M A Suresh Kumar

4

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Europe PubMed Central

12 September 2017

Mangalam S Nair

5

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Europe PubMed Central

12 September 2017

Priya Srinivas

6

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Europe PubMed Central

12 September 2017

Srinivas Gopala

7

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Europe PubMed Central

12 September 2017

publication date

15 June 2011

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Europe PubMed Central

12 September 2017

Molecular Carcinogenesis

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Europe PubMed Central

12 September 2017

51

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12 September 2017

6

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12 September 2017

475-490

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Europe PubMed Central

12 September 2017

Insect antifeedant activity of tetranortriterpenoids from the Rutales. A perusal of structural relations

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Cytotoxicity of nimbolide, epoxyazadiradione and other limonoids from neem insecticide

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Spectroscopic and biological investigation of nimbolide and 28-deoxonimbolide from Azadirachta indica

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https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Synthesis and biological activity of amide derivatives of nimbolide

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https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Inhibition of colon cancer (HT-29) cell proliferation by a triterpenoid isolated from Azadirachta indica is accompanied by cell cycle arrest and up-regulation of p21.

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis.

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Antisense blocking of BRCA1 enhances sensitivity to plumbagin but not tamoxifen in BG-1 ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Inhibition of matrix metalloproteinase-9 gene expression by an isoflavone metabolite, irisolidone in U87MG human astroglioma cells

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion, and metastasis via iNOS-mediated MMP-2 production

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Regulation of matrix metalloproteinase gene expression

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

4-Hydroxynonenal enhances MMP-2 production in vascular smooth muscle cells via mitochondrial ROS-mediated activation of the Akt/NF-kappaB signaling pathways

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences.

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Glucocorticoid-mediated suppression of cytokine-induced matrix metalloproteinase-9 expression in rat mesangial cells: involvement of nuclear factor-kappaB and Ets transcription factors

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Antiproliferative effect on human cancer cell lines after treatment with nimbolide extracted from an edible part of the neem tree (Azadirachta indica).

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Mammalian MAP kinase signalling cascades

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

The stress-activated protein kinase pathways

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Expression profiling of epithelial plasticity in tumor progression

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

CADPE inhibits PMA-stimulated gastric carcinoma cell invasion and matrix metalloproteinase-9 expression by FAK/MEK/ERK-mediated AP-1 activation.

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Suppression of PMA-induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgaris via the inhibition of NF-kappaB-dependent MMP-9 expression.

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Suppression of PMA-induced tumor cell invasion by dihydroartemisinin via inhibition of PKCalpha/Raf/MAPKs and NF-kappaB/AP-1-dependent mechanisms.

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by bergamottin via the inhibition of protein kinase Cdelta/p38 mitogen-activated protein kinase and JNK/nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression.

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

The neem limonoids azadirachtin and nimbolide inhibit hamster cheek pouch carcinogenesis by modulating xenobiotic-metabolizing enzymes, DNA damage, antioxidants, invasion and angiogenesis.

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Role of matrix metalloproteinases (MMPs) in colorectal cancer

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Biological properties of VEGF/VPF receptors

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

MAP kinase signalling pathways in cancer

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Aberrant rel/nfkb genes and activity in human cancer

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor-kappaB p52, which is associated with hyperphosphorylated Bcl-3

1 reference

https://api.crossref.org/works/10.1002%2FMC.20812

21 January 2018

Identifiers

10.1002/MC.20812

1 reference

Europe PubMed Central

12 September 2017

1 reference

Europe PubMed Central

12 September 2017

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