ERK and PDE4 cooperate to induce RAF isoform switching in melanoma (Q39561513)

13 September 2017

ERK and PDE4 cooperate to induce RAF isoform switching in melanoma (English)

1 reference

13 September 2017

Braf transforming gene

1 reference

V-raf-leukemia viral oncogene 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Amélie Marquette

1

1 reference

13 September 2017

Jocelyne André

2

1 reference

13 September 2017

Martine Bagot

3

1 reference

13 September 2017

Armand Bensussan

4

1 reference

13 September 2017

Nicolas Dumaz

5

1 reference

13 September 2017

10 April 2011

1 reference

Nature Structural & Molecular Biology

13 September 2017

1 reference

13 September 2017

18

1 reference

13 September 2017

584-591

1 reference

13 September 2017

5

1 reference

https://scigraph.springernature.com/pub.10.1038/nsmb.2022

13 September 2017

0 references

cites work

Epidemiology of invasive cutaneous melanoma

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Role of keratinocyte-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes

31 March 2020

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Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft für Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels

31 March 2020

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Integrating signals from RTKs to ERK/MAPK.

31 March 2020

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Ras oncogenes: split personalities

31 March 2020

1 reference

The RAF proteins take centre stage

31 March 2020

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MAP kinases and the control of nuclear events

31 March 2020

1 reference

Anal mucosal melanoma with KIT-activating mutation and response to imatinib therapy--case report and review of the literature

31 March 2020

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c-Kit mutants require hypoxia-inducible factor 1alpha to transform melanocytes

31 March 2020

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Mutations of the BRAF gene in human cancer

31 March 2020

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Guilty as charged: B-RAF is a human oncogene

31 March 2020

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V599EB-RAF is an oncogene in melanocytes

31 March 2020

1 reference

In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling

31 March 2020

1 reference

G-protein-coupled receptors and melanoma

31 March 2020

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Melanocyte biology and skin pigmentation

31 March 2020

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Fifteen-year quest for microphthalmia-associated transcription factor target genes

31 March 2020

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PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

31 March 2020

1 reference

Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract

31 March 2020

1 reference

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

31 March 2020

1 reference

Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

31 March 2020

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Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling

31 March 2020

1 reference

Overview of PDEs and their regulation

31 March 2020

1 reference

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

31 March 2020

1 reference

A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth

31 March 2020

1 reference

Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform

31 March 2020

1 reference

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

31 March 2020

1 reference

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

31 March 2020

1 reference

Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma

31 March 2020

1 reference

Signaling dynamics of the KSR1 scaffold complex

31 March 2020

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Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf

31 March 2020

1 reference

Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling

31 March 2020

1 reference

Regulation of Raf-1 by direct feedback phosphorylation.

31 March 2020

1 reference

The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.

31 March 2020

1 reference

ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions

31 March 2020

1 reference

Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases

31 March 2020

1 reference

Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuit

31 March 2020

1 reference

Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.

31 March 2020

1 reference

Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase

31 March 2020

1 reference

PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A.

31 March 2020

1 reference

Melanoma from bench to bedside: meeting report from the 6th international melanoma congress.

31 March 2020

1 reference

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

31 March 2020

1 reference

BRAF mutation predicts sensitivity to MEK inhibition

31 March 2020

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Phosphodiesterase-4 inhibition in COPD.

31 March 2020

1 reference

Stable silencing of SNAP-25 in PC12 cells by RNA interference

31 March 2020

1 reference

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

31 March 2020

1 reference

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3

31 March 2020

1 reference

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

31 March 2020

1 reference

Insulin trigger, cyclic AMP-dependent activation and phosphorylation of a plasma membrane cyclic AMP phosphodiesterase

31 March 2020

1 reference

BRAF and RAS mutations in human lung cancer and melanoma

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21478863

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mitogen-actived protein kinase activation is an early event in melanoma progression.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21478863

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.2022

1 reference

Dimensions Publication ID

13 September 2017

1036046219

0 references

Fatcat ID

release_5qu7m7mk6jgthoo6hmbl4e6bie

0 references

1 reference